Seroatlas · Human Serome Atlas

UBFD1

Ubiquitin domain-containing protein UBFD1

Also known as: FLJ38870, FLJ42145, UBFD1_HUMAN, UBPH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14562
Gene: UBFD1
Ensembl: ENSG00000103353
Chromosome: 16
Canonical length: 309 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables RNA binding activity and cadherin binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>O14562|UBFD1
     1  MAAAGAPDGM EEPGMDTEAE TVATEAPARP VNCLEAEAAA GAAAEDSGAA RGSLQPAPAQ
    61  PPGDPAAQAS VSNGEDAGGG AGRELVDLKI IWNKTKHDVK FPLDSTGSEL KQKIHSITGL
   121  PPAMQKVMYK GLVPEDKTLR EIKVTSGAKI MVVGSTINDV LAVNTPKDAA QQDAKAEENK
   181  KEPLCRQKQH RKVLDKGKPE DVMPSVKGAQ ERLPTVPLSG MYNKSGGKVR LTFKLEQDQL
   241  WIGTKERTEK LPMGSIKNVV SEPIEGHEDY HMMAFQLGPT EASYYWVYWV PTQYVDAIKD
   301  TVLGKWQYF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBFD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 75 nTPM
tongue: 36 nTPM
cerebellum: 26 nTPM
testis: 24 nTPM
parathyroid gland: 24 nTPM
hypothalamus: 20 nTPM

Single-cell type

late spermatids: 111 nCPM
early spermatids: 74 nCPM
myonuclei: 69 nCPM
adrenal medulla cells: 53 nCPM
syncytiotrophoblasts: 45 nCPM
thymic myoid cells: 37 nCPM

Immune cell

plasmacytoid DC: 1.5 nTPM
gdT-cell: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM
naive B-cell: 1.3 nTPM
NK-cell: 1.2 nTPM
myeloid DC: 1.1 nTPM

Brain region

pons: 52 nTPM
choroid plexus: 49 nTPM
hypothalamus: 47 nTPM
midbrain: 42 nTPM
medulla oblongata: 39 nTPM
thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.94
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Ubiquitin-like domain
Ubiquitin conserved site
Ubiquitin-like domain superfamily
Ubiquitin family
Ubiquitin domain-containing protein UBFD1
UBFD1, PH-like C-terminal domain
C-terminal PH-like domain in UBFD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBFD1 as an antibody target. Whether an autoantibody or antibody against UBFD1 could matter depends on whether native UBFD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBFD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBFD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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