Seroatlas · Human Serome Atlas

UBC

Polyubiquitin-C

Also known as: UBC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CG48
Gene
UBC
Ensembl
ENSG00000150991
Chromosome
12
Canonical length
685 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol,Acrosome,Equatorial segment

OverviewNCBI Gene

This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

685 residues, UniProt reviewed canonical sequence.

>P0CG48|UBC
     1  MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
    61  IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI
   121  FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA
   181  KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT
   241  ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR
   301  LRGGMQIFVK TLTGKTITLE VEPSDTIENV KAKIQDKEGI PPDQQRLIFA GKQLEDGRTL
   361  SDYNIQKEST LHLVLRLRGG MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ
   421  QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE
   481  NVKAKIQDKE GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL
   541  TGKTITLEVE PSDTIENVKA KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH
   601  LVLRLRGGMQ IFVKTLTGKT ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED
   661  GRTLSDYNIQ KESTLHLVLR LRGGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
3,527 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 3,527 nTPM
  • tongue: 2,968 nTPM
  • bone marrow: 2,648 nTPM
  • choroid plexus: 2,136 nTPM
  • liver: 1,545 nTPM
  • esophagus: 1,542 nTPM

Single-cell type

  • esophageal apical cells: 12,837 nCPM
  • late spermatids: 5,575 nCPM
  • early spermatids: 4,803 nCPM
  • esophageal suprabasal cells: 3,216 nCPM
  • late primary spermatocytes: 3,040 nCPM
  • epididymal basal cells: 2,884 nCPM

Immune cell

  • total PBMC: 1,020 nTPM
  • neutrophil: 994 nTPM
  • non-classical monocyte: 657 nTPM
  • eosinophil: 608 nTPM
  • classical monocyte: 532 nTPM
  • intermediate monocyte: 518 nTPM

Brain region

  • cerebral cortex: 1,792 nTPM
  • white matter: 1,688 nTPM
  • cerebellum: 1,144 nTPM
  • choroid plexus: 1,113 nTPM
  • medulla oblongata: 1,096 nTPM
  • hypothalamus: 1,063 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.14
gnomAD missense Z
3.53
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBC as an antibody target. Whether an autoantibody or antibody against UBC could matter depends on whether native UBC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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