Seroatlas · Human Serome Atlas

UBL5

Ubiquitin-like protein 5

Also known as: UBL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZL1
Gene: UBL5
Ensembl: ENSG00000198258
Chromosome: 19
Canonical length: 73 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

73 residues, UniProt reviewed canonical sequence.

>Q9BZL1|UBL5
     1  MIEVVCNDRL GKKVRVKCNT DDTIGDLKKL IAAQTGTRWN KIVLKKWYTI FKDHVSLGDY
    61  EIHDGMNLEL YYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 879 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 879 nTPM
heart muscle: 674 nTPM
amygdala: 653 nTPM
kidney: 602 nTPM
basal ganglia: 598 nTPM
skeletal muscle: 563 nTPM

Single-cell type

esophageal apical cells: 2,232 nCPM
esophageal suprabasal cells: 1,150 nCPM
hepatocytes: 1,035 nCPM
megakaryocytes: 1,026 nCPM
enterocytes: 1,007 nCPM
parietal cells: 999 nCPM

Immune cell

eosinophil: 1,277 nTPM
basophil: 871 nTPM
neutrophil: 826 nTPM
plasmacytoid DC: 783 nTPM
total PBMC: 758 nTPM
T-reg: 621 nTPM

Brain region

choroid plexus: 256 nTPM
white matter: 249 nTPM
hypothalamus: 211 nTPM
spinal cord: 211 nTPM
cerebellum: 186 nTPM
cerebral cortex: 183 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0.02
gnomAD missense Z: 1.24
DepMap mean gene effect: -2.66
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein tag activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBL5 as an antibody target. Whether an autoantibody or antibody against UBL5 could matter depends on whether native UBL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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