Seroatlas · Human Serome Atlas

UBL4B

Ubiquitin-like protein 4B

Also known as: FLJ25690, UBL4B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7F7
Gene: UBL4B
Ensembl: ENSG00000186150
Chromosome: 1
Canonical length: 174 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

174 residues, UniProt reviewed canonical sequence.

>Q8N7F7|UBL4B
     1  MFLTVKLLLG QRCSLKVSGQ ESVATLKRLV SRRLKVPEEQ QHLLFRGQLL EDDKHLSDYC
    61  IGPNASINVI MQPLEKMALK EAHQPQTQPL WHQLGLVLAK HFEPQDAKAV LQLLRQEHEE
   121  RLQKISLEHL EQLAQYLLAE EPHVEPAGER ELEAKARPQS SCDMEEKEEA AADQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBL4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

testis: 104 nTPM
choroid plexus: 3.1 nTPM
pituitary gland: 1.1 nTPM
tongue: 0.7 nTPM
breast: 0.6 nTPM
fallopian tube: 0.6 nTPM

Single-cell type

late spermatids: 11,618 nCPM
early spermatids: 1,601 nCPM
late primary spermatocytes: 587 nCPM
oocytes: 83 nCPM
sertoli cells: 18 nCPM
leydig cells: 13 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 4.8 nTPM
choroid plexus: 3.8 nTPM
midbrain: 3 nTPM
hypothalamus: 2.2 nTPM
cerebral cortex: 2.1 nTPM
amygdala: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0.03
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of protein targeting to mitochondrion

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBL4B as an antibody target. Whether an autoantibody or antibody against UBL4B could matter depends on whether native UBL4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBL4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBL4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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