Seroatlas · Human Serome Atlas

ELOB

Elongin-B

Also known as: ELOB_HUMAN, SIII, TCEB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15370
Gene
ELOB
Ensembl
ENSG00000103363
Chromosome
16
Canonical length
118 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>Q15370|ELOB
     1  MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC
    61  GFTSQTARPQ APATVGLAFR ADDTFEALCI EPFSSPPELP DVMKPQDSGS SANEQAVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELOB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
556 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 556 nTPM
  • choroid plexus: 535 nTPM
  • amygdala: 473 nTPM
  • heart muscle: 436 nTPM
  • basal ganglia: 420 nTPM
  • hippocampal formation: 405 nTPM

Single-cell type

  • late spermatids: 12,046 nCPM
  • late primary spermatocytes: 2,194 nCPM
  • early spermatids: 2,020 nCPM
  • colonocytes: 1,834 nCPM
  • esophageal apical cells: 1,509 nCPM
  • enterocytes: 1,250 nCPM

Immune cell

  • basophil: 3,234 nTPM
  • eosinophil: 3,141 nTPM
  • total PBMC: 2,386 nTPM
  • classical monocyte: 1,689 nTPM
  • neutrophil: 1,651 nTPM
  • non-classical monocyte: 1,324 nTPM

Brain region

  • thalamus: 272 nTPM
  • white matter: 268 nTPM
  • hippocampal formation: 265 nTPM
  • cerebellum: 261 nTPM
  • hypothalamus: 261 nTPM
  • spinal cord: 260 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.33
gnomAD pLI
0.09
DepMap mean gene effect
-1.39
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELOB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELOB as an antibody target. Whether an autoantibody or antibody against ELOB could matter depends on whether native ELOB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELOB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELOB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ELOB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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