DEAD/DEAH-box helicase domain
IPR011545
Definition
This entry represents the DNA-binding domain at the N-terminal in DEAD/DEAH box helicase and related proteins. This domain also contains motif III (S-A-T) which was proposed to participate in linking ATPase and helicase activities. DEAD-box and DEAH-box RNA helicases are essential enzymes involved in the unwinding of nucleic acids, playing critical roles in RNA metabolism. The DEAD-box helicases, exemplified by the translation initiation factor eIF4A, are RNA-dependent ATPases that act as RNA helicases in conjunction with eIF4B. These proteins participate in a wide range of processes including nuclear transcription, pre-mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. In contrast, DEAH-box helicases are primarily involved in pre-mRNA splicing and function as ATP-dependent RNA helicases [[cite:PMID:16935882], [cite:PMID:20941364], [cite:PMID:11545728]].
71 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (71 proteins: gene, accession, name)
- ASCC3
- BLM
- DDX1
- DDX10
- DDX17
- DDX18
- DDX19A
- DDX19B
- DDX20
- DDX21
- DDX23
- DDX24
- DDX25
- DDX27
- DDX28
- DDX31
- DDX39A
- DDX39B
- DDX3X
- DDX3Y
- DDX4
- DDX41
- DDX42
- DDX43
- DDX46
- DDX47
- DDX49
- DDX5
- DDX50
- DDX51
- DDX52
- DDX53
- DDX54
- DDX55
- DDX56
- DDX59
- DDX6
- DDX60
- DDX60L
- DHX15
- DHX16
- DHX29
- DHX30
- DHX33
- DHX34
- DHX36
- DHX37
- DHX38
- DHX40
- DHX57
- DHX8
- DHX9
- DICER1
- EIF4A1
- EIF4A2
- EIF4A3
- FANCM
- HELQ
- HFM1
- MTREX
- POLQ
- RECQL
- RECQL4
- RECQL5
- RIGI
- SKIC2
- SNRNP200
- TDRD12
- TDRD9
- WRN
- YTHDC2
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