EGF-type aspartate/asparagine hydroxylation site
IPR000152
Definition
Post-translational hydroxylation of aspartic acid or asparagine PMID:2826439 to form erythro-beta-hydroxyaspartic acid or erythro-beta-hydroxyasparagine has been identified in a number of proteins with domains homologous to epidermal growth factor (EGF). Examples of such proteins are the blood coagulation protein factors VII, IX and X, proteins C, S, and Z, the LDL receptor, thrombomodulin, etc. Based on sequence comparisons of the EGF-homology region that contains hydroxylated Asp or Asn, a consensus sequence has been identified that seems to be required by the hydroxylase(s).
100 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (100 proteins: gene, accession, name)
- ADGRE1
- ADGRE2
- ADGRE3
- ADGRE4P
- ADGRE5
- ADGRL4
- BMP1
- C1S
- CCBE1
- CD93
- CELSR1
- CELSR2
- CRB1
- CRB2
- CRELD1
- CRELD2
- CUBN
- DLK1
- DLK2
- DLL1
- DLL4
- DNER
- EDIL3
- EFEMP1
- EFEMP2
- EGF
- EGFL6
- EGFL8
- EYS
- F10
- F7
- F9
- FAT1
- FAT3
- FAT4
- FBLN1
- FBLN2
- FBLN5
- FBLN7
- FBN1
- FBN2
- FBN3
- GAS6
- HEG1
- HMCN1
- HMCN2
- JAG1
- JAG2
- LDLR
- LRP1
- LRP1B
- LRP2
- LRP8
- LTBP1
- LTBP2
- LTBP3
- LTBP4
- MASP2
- MATN2
- MEGF6
- MEGF8
- MMRN1
- NBPF26
- NCAN
- NELL1
- NELL2
- NID1
- NID2
- NOTCH1
- NOTCH2
- NOTCH2NLA
- NOTCH2NLB
- NOTCH2NLC
- NOTCH2NLR
- NOTCH3
- NOTCH4
- NPNT
- NRXN1
- NRXN3
- PROC
- PROS1
- PROZ
- SCUBE1
- SCUBE2
- SCUBE3
- SLIT1
- SLIT2
- SLIT3
- SNED1
- SUSD1
- SVEP1
- THBD
- TLL1
- TLL2
- TPO
- UMOD
- UMODL1
- VCAN
- VLDLR
- VWCE
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