Seroatlas · Human Serome Atlas

SNED1

Sushi, nidogen and EGF-like domain-containing protein 1

Also known as: FLJ00133, SNED1_HUMAN, Snep, SST3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TER0
Gene: SNED1
Ensembl: ENSG00000162804
Chromosome: 2
Canonical length: 1413 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable Notch binding activity. Predicted to be involved in cell-matrix adhesion. Located in extracellular matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1413 residues, UniProt reviewed canonical sequence.

>Q8TER0|SNED1
     1  MRHGVAWALL VAAALGLGAR GVRGAVALAD FYPFGAERGD AVTPKQDDGG SGLRPLSVPF
    61  PFFGAEHSGL YVNNNGIISF LKEVSQFTPV AFPIAKDRCV VAAFWADVDN RRAGDVYYRE
   121  ATDPAMLRRA TEDVRHYFPE LLDFNATWVF VATWYRVTFF GGSSSSPVNT FQTVLITDGK
   181  LSFTIFNYES IVWTTGTHAS SGGNATGLGG IAAQAGFNAG DGQRYFSIPG SRTADMAEVE
   241  TTTNVGVPGR WAFRIDDAQV RVGGCGHTTS VCLALRPCLN GGKCIDDCVT GNPSYTCSCL
   301  SGFTGRRCHL DVNECASQPC QNGGTCTHGI NSFRCQCPAG FGGPTCETAQ SPCDTKECQH
   361  GGQCQVENGS AVCVCQAGYT GAACEMDVDD CSPDPCLNGG SCVDLVGNYT CLCAEPFKGL
   421  RCETGDHPVP DACLSAPCHN GGTCVDADQG YVCECPEGFM GLDCRERVPD DCECRNGGRC
   481  LGANTTLCQC PLGFFGLLCE FEITAMPCNM NTQCPDGGYC MEHGGSYLCV CHTDHNASHS
   541  LPSPCDSDPC FNGGSCDAHD DSYTCECPRG FHGKHCEKAR PHLCSSGPCR NGGTCKEAGG
   601  EYHCSCPYRF TGRHCEIGKP DSCASGPCHN GGTCFHYIGK YKCDCPPGFS GRHCEIAPSP
   661  CFRSPCVNGG TCEDRDTDFF CHCQAGYMGR RCQAEVDCGP PEEVKHATLR FNGTRLGAVA
   721  LYACDRGYSL SAPSRIRVCQ PHGVWSEPPQ CLEIDECRSQ PCLHGGSCQD RVAGYLCLCS
   781  TGYEGAHCEL ERDECRAHPC RNGGSCRNLP GAYVCRCPAG FVGVHCETEV DACDSSPCQH
   841  GGRCESGGGA YLCVCPESFF GYHCETVSDP CFSSPCGGRG YCLASNGSHS CTCKVGYTGE
   901  DCAKELFPPT ALKMERVEES GVSISWNPPN GPAARQMLDG YAVTYVSSDG SYRRTDFVDR
   961  TRSSHQLQAL AAGRAYNISV FSVKRNSNNK NDISRPAVLL ARTRPRPVEG FEVTNVTAST
  1021  ISVQWALHRI RHATVSGVRV SIRHPEALRD QATDVDRSVD RFTFRALLPG KRYTIQLTTL
  1081  SGLRGEEHPT ESLATAPTHV WTRPLPPANL TAARVTATSA HVVWDAPTPG SLLEAYVINV
  1141  TTSQSTKSRY VPNGKLASYT VRDLLPGRRY QLSVIAVQST ELGPQHSEPA HLYIITSPRD
  1201  GADRRWHQGG HHPRVLKNRP PPARLPELRL LNDHSAPETP TQPPRFSELV DGRGRVSARF
  1261  GGSPSKAATV RSQPTASAQL ENMEEAPKRV SLALQLPEHG SKDIGNVPGN CSENPCQNGG
  1321  TCVPGADAHS CDCGPGFKGR RCELACIKVS RPCTRLFSET KAFPVWEGGV CHHVYKRVYR
  1381  VHQDICFKES CESTSLKKTP NRKQSKSQTL EKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

cervix: 29 nTPM
thyroid gland: 28 nTPM
blood vessel: 27 nTPM
adipose tissue: 22 nTPM
ovary: 20 nTPM
fallopian tube: 20 nTPM

Single-cell type

leydig cells: 1,952 nCPM
myosatellite cells: 1,062 nCPM
peritubular myoid cells: 963 nCPM
fibro-adipogenic progenitors: 680 nCPM
choroid plexus epithelial cells: 542 nCPM
bergmann glia: 534 nCPM

Immune cell

memory B-cell: 1.9 nTPM
naive B-cell: 0.7 nTPM
non-classical monocyte: 0.7 nTPM
memory CD4 T-cell: 0.4 nTPM
T-reg: 0.4 nTPM
intermediate monocyte: 0.3 nTPM

Brain region

choroid plexus: 89 nTPM
cerebellum: 50 nTPM
hypothalamus: 47 nTPM
hippocampal formation: 43 nTPM
cerebral cortex: 39 nTPM
medulla oblongata: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.66
gnomAD missense Z: 3.13
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell-matrix adhesion

Molecular functions

Cellular components

extracellular matrix

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNED1 as an antibody target. Whether an autoantibody or antibody against SNED1 could matter depends on whether native SNED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNED1 is annotated as secreted, so native SNED1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SNED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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