Seroatlas · Human Serome Atlas

NPNT

Nephronectin

Also known as: EGFL6L, NPNT_HUMAN, POEM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXI9
Gene
NPNT
Ensembl
ENSG00000168743
Chromosome
4
Canonical length
565 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Cell Junctions,Cytosol
Secretome location
Secreted to extracellular matrix
Quaternary structure
Homotrimer

OverviewNCBI Gene

Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by integrin; positive regulation of ERK1 and ERK2 cascade; and positive regulation of alkaline phosphatase activity. Predicted to act upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway. Located in collagen-containing extracellular matrix and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

565 residues, UniProt reviewed canonical sequence.

>Q6UXI9|NPNT
     1  MDFLLALVLV SSLYLQAAAE FDGRWPRQIV SSIGLCRYGG RIDCCWGWAR QSWGQCQPVC
    61  QPRCKHGECI GPNKCKCHPG YAGKTCNQDL NECGLKPRPC KHRCMNTYGS YKCYCLNGYM
   121  LMPDGSCSSA LTCSMANCQY GCDVVKGQIR CQCPSPGLQL APDGRTCVDV DECATGRASC
   181  PRFRQCVNTF GSYICKCHKG FDLMYIGGKY QCHDIDECSL GQYQCSSFAR CYNIRGSYKC
   241  KCKEGYQGDG LTCVYIPKVM IEPSGPIHVP KGNGTILKGD TGNNNWIPDV GSTWWPPKTP
   301  YIPPIITNRP TSKPTTRPTP KPTPIPTPPP PPPLPTELRT PLPPTTPERP TTGLTTIAPA
   361  ASTPPGGITV DNRVQTDPQK PRGDVFIPRQ PSNDLFEIFE IERGVSADDE AKDDPGVLVH
   421  SCNFDHGLCG WIREKDNDLH WEPIRDPAGG QYLTVSAAKA PGGKAARLVL PLGRLMHSGD
   481  LCLSFRHKVT GLHSGTLQVF VRKHGAHGAA LWGRNGGHGW RQTQITLRGA DIKSVVFKGE
   541  KRRGHTGEIG LDDVSLKKGH CSEER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPNT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
225 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 225 nTPM
  • blood vessel: 185 nTPM
  • lung: 132 nTPM
  • kidney: 100 nTPM
  • prostate: 78 nTPM
  • small intestine: 70 nTPM

Single-cell type

  • podocytes: 1,852 nCPM
  • alveolar cells type 1: 493 nCPM
  • pituicytes/fscs: 452 nCPM
  • transitional alveolar cells: 388 nCPM
  • alveolar cells type 2: 323 nCPM
  • renal collecting duct intercalated cells: 200 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 64 nTPM
  • hypothalamus: 24 nTPM
  • thalamus: 15 nTPM
  • amygdala: 13 nTPM
  • pons: 12 nTPM
  • basal ganglia: 9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NPNT.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 129 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
-0.09
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NPNT as an antibody target. Whether an autoantibody or antibody against NPNT could matter depends on whether native NPNT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NPNT is annotated as secreted, so native NPNT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NPNT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NPNT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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