Seroatlas · Human Serome Atlas

NELL2

Protein kinase C-binding protein NELL2

Also known as: NELL2_HUMAN, NRP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99435
Gene
NELL2
Ensembl
ENSG00000184613
Chromosome
12
Canonical length
816 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to blood
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

816 residues, UniProt reviewed canonical sequence.

>Q99435|NELL2
     1  MESRVLLRTF CLIFGLGAVW GLGVDPSLQI DVLTELELGE STTGVRQVPG LHNGTKAFLF
    61  QDTPRSIKAS TATAEQFFQK LRNKHEFTIL VTLKQTHLNS GVILSIHHLD HRYLELESSG
   121  HRNEVRLHYR SGSHRPHTEV FPYILADDKW HKLSLAISAS HLILHIDCNK IYERVVEKPS
   181  TDLPLGTTFW LGQRNNAHGY FKGIMQDVQL LVMPQGFIAQ CPDLNRTCPT CNDFHGLVQK
   241  IMELQDILAK TSAKLSRAEQ RMNRLDQCYC ERTCTMKGTT YREFESWIDG CKNCTCLNGT
   301  IQCETLICPN PDCPLKSALA YVDGKCCKEC KSICQFQGRT YFEGERNTVY SSSGVCVLYE
   361  CKDQTMKLVE SSGCPALDCP ESHQITLSHS CCKVCKGYDF CSERHNCMEN SICRNLNDRA
   421  VCSCRDGFRA LREDNAYCED IDECAEGRHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC
   481  TEHDECITNQ HNCDENALCF NTVGGHNCVC KPGYTGNGTT CKAFCKDGCR NGGACIAANV
   541  CACPQGFTGP SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC
   601  EDIDECGTGR HSCANDTICF NLDGGYDCRC PHGKNCTGDC IHDGKVKHNG QIWVLENDRC
   661  SVCSCQNGFV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQNGETLYN SGDTWVQNCQ
   721  QCRCLQGEVD CWPLPCPDVE CEFSILPENE CCPRCVTDPC QADTIRNDIT KTCLDEMNVV
   781  RFTGSSWIKH GTECTLCQCK NGHICCSVDP QCLQEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NELL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
120 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 120 nTPM
  • cerebral cortex: 117 nTPM
  • hippocampal formation: 79 nTPM
  • retina: 79 nTPM
  • fallopian tube: 57 nTPM
  • hypothalamus: 40 nTPM

Single-cell type

  • thyrotrophs: 815 nCPM
  • brain excitatory neurons: 759 nCPM
  • choroid plexus epithelial cells: 588 nCPM
  • retinal pigment epithelial cells: 567 nCPM
  • ependymal cells: 498 nCPM
  • lactotrophs: 445 nCPM

Immune cell

  • naive CD8 T-cell: 111 nTPM
  • naive CD4 T-cell: 71 nTPM
  • memory CD8 T-cell: 53 nTPM
  • memory CD4 T-cell: 30 nTPM
  • total PBMC: 27 nTPM
  • MAIT T-cell: 25 nTPM

Brain region

  • cerebral cortex: 328 nTPM
  • hippocampal formation: 293 nTPM
  • choroid plexus: 235 nTPM
  • basal ganglia: 192 nTPM
  • white matter: 191 nTPM
  • amygdala: 105 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
0.73
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NELL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NELL2 as an antibody target. Whether an autoantibody or antibody against NELL2 could matter depends on whether native NELL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NELL2 is annotated as secreted, so native NELL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NELL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NELL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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