Seroatlas · Human Serome Atlas

ADGRE3

Adhesion G protein-coupled receptor E3

Also known as: AGRE3_HUMAN, EMR3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BY15
Gene
ADGRE3
Ensembl
ENSG00000131355
Chromosome
19
Canonical length
652 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q9BY15|ADGRE3
     1  MQGPLLLPGL CFLLSLFGAV TQKTKTSCAK CPPNASCVNN THCTCNHGYT SGSGQKLFTF
    61  PLETCNDINE CTPPYSVYCG FNAVCYNVEG SFYCQCVPGY RLHSGNEQFS NSNENTCQDT
   121  TSSKTTEGRK ELQKIVDKFE SLLTNQTLWR TEGRQEISST ATTILRDVES KVLETALKDP
   181  EQKVLKIQND SVAIETQAIT DNCSEERKTF NLNVQMNSMD IRCSDIIQGD TQGPSAIAFI
   241  SYSSLGNIIN ATFFEEMDKK DQVYLNSQVV SAAIGPKRNV SLSKSVTLTF QHVKMTPSTK
   301  KVFCVYWKST GQGSQWSRDG CFLIHVNKSH TMCNCSHLSS FAVLMALTSQ EEDPVLTVIT
   361  YVGLSVSLLC LLLAALTFLL CKAIRNTSTS LHLQLSLCLF LAHLLFLVGI DRTEPKVLCS
   421  IIAGALHYLY LAAFTWMLLE GVHLFLTARN LTVVNYSSIN RLMKWIMFPV GYGVPAVTVA
   481  ISAASWPHLY GTADRCWLHL DQGFMWSFLG PVCAIFSANL VLFILVFWIL KRKLSSLNSE
   541  VSTIQNTRML AFKATAQLFI LGCTWCLGLL QVGPAAQVMA YLFTIINSLQ GFFIFLVYCL
   601  LSQQVQKQYQ KWFREIVKSK SESETYTLSS KMGPDSKPSE GDVFPGQVKR KY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
5.7 nTPM

Expression across tissuesHPA

Tissue

  • appendix: 5.7 nTPM
  • spleen: 5.6 nTPM
  • bone marrow: 3 nTPM
  • lung: 2.4 nTPM
  • small intestine: 2.2 nTPM
  • tonsil: 2.2 nTPM

Single-cell type

  • neutrophils: 370 nCPM
  • neutrophil progenitors: 31 nCPM
  • cardiomyocytes: 28 nCPM
  • monocytes: 18 nCPM
  • epicardial cells: 9.1 nCPM
  • macrophages: 8.2 nCPM

Immune cell

  • eosinophil: 510 nTPM
  • neutrophil: 492 nTPM
  • basophil: 283 nTPM
  • non-classical monocyte: 62 nTPM
  • intermediate monocyte: 53 nTPM
  • classical monocyte: 22 nTPM

Brain region

  • cerebral cortex: 1.1 nTPM
  • pons: 0.5 nTPM
  • medulla oblongata: 0.2 nTPM
  • thalamus: 0.2 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRE3 as an antibody target. Whether an autoantibody or antibody against ADGRE3 could matter depends on whether native ADGRE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRE3 is annotated at the cell surface, where native ADGRE3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADGRE3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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