EGFL6

Protein identityUniProt · HPA

UniProt accession

Q8IUX8

Gene

EGFL6

Ensembl

ENSG00000198759

Chromosome

X

Canonical length

553 aa

Protein class

Predicted secreted proteins

Secretome location

Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q8IUX8|EGFL6
     1  MPLPWSLALP LLLSWVAGGF GNAASARHHG LLASARQPGV CHYGTKLACC YGWRRNSKGV
    61  CEATCEPGCK FGECVGPNKC RCFPGYTGKT CSQDVNECGM KPRPCQHRCV NTHGSYKCFC
   121  LSGHMLMPDA TCVNSRTCAM INCQYSCEDT EEGPQCLCPS SGLRLAPNGR DCLDIDECAS
   181  GKVICPYNRR CVNTFGSYYC KCHIGFELQY ISGRYDCIDI NECTMDSHTC SHHANCFNTQ
   241  GSFKCKCKQG YKGNGLRCSA IPENSVKEVL RAPGTIKDRI KKLLAHKNSM KKKAKIKNVT
   301  PEPTRTPTPK VNLQPFNYEE IVSRGGNSHG GKKGNEEKMK EGLEDEKREE KALKNDIEER
   361  SLRGDVFFPK VNEAGEFGLI LVQRKALTSK LEHKDLNISV DCSFNHGICD WKQDREDDFD
   421  WNPADRDNAI GFYMAVPALA GHKKDIGRLK LLLPDLQPQS NFCLLFDYRL AGDKVGKLRV
   481  FVKNSNNALA WEKTTSEDEK WKTGKIQLYQ GTDATKSIIF EAERGKGKTG EIAVDGVLLV
   541  SGLCPDSLLS VDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EGFL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

606 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.29

gnomAD pLI

0

gnomAD missense Z

0.64

DepMap mean gene effect

0.2

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• cell differentiation
• extracellular matrix organization
• positive regulation of cell-substrate adhesion

Molecular functions

• calcium ion binding
• integrin binding

Cellular components

• basement membrane
• extracellular space
• membrane

Protein domainsUniProt · Pfam · InterPro

• EGF-type aspartate/asparagine hydroxylation site
• EGF-like domain
• MAM domain
• EGF-like calcium-binding domain
• Growth factor receptor cysteine-rich domain superfamily
• Concanavalin A-like lectin/glucanase domain superfamily
• EGF-like calcium-binding, conserved site
• NOTCH1, EGF-like calcium-binding domain
• Nephronectin domain-containing protein
• MAM domain, meprin/A5/mu
• Calcium-binding EGF domain

KeywordsUniProt

• Basement membrane
• Calcium
• Cell adhesion
• Coiled coil
• Developmental protein
• Differentiation
• Disulfide bond
• EGF-like domain
• Extracellular matrix
• Glycoprotein
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of EGFL6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SH3GL2