Seroatlas · Human Serome Atlas

EDIL3

EGF-like repeat and discoidin I-like domain-containing protein 3

Also known as: DEL1, EDIL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43854
Gene
EDIL3
Ensembl
ENSG00000164176
Chromosome
5
Canonical length
480 aa
Protein class
Predicted secreted proteins
Subcellular location
Plasma membrane
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>O43854|EDIL3
     1  MKRSVAVWLL VGLSLGVPQF GKGDICDPNP CENGGICLPG LADGSFSCEC PDGFTDPNCS
    61  SVVEVASDEE EPTSAGPCTP NPCHNGGTCE ISEAYRGDTF IGYVCKCPRG FNGIHCQHNI
   121  NECEVEPCKN GGICTDLVAN YSCECPGEFM GRNCQYKCSG PLGIEGGIIS NQQITASSTH
   181  RALFGLQKWY PYYARLNKKG LINAWTAAEN DRWPWIQINL QRKMRVTGVI TQGAKRIGSP
   241  EYIKSYKIAY SNDGKTWAMY KVKGTNEDMV FRGNIDNNTP YANSFTPPIK AQYVRLYPQV
   301  CRRHCTLRME LLGCELSGCS EPLGMKSGHI QDYQITASSI FRTLNMDMFT WEPRKARLDK
   361  QGKVNAWTSG HNDQSQWLQV DLLVPTKVTG IITQGAKDFG HVQFVGSYKL AYSNDGEHWT
   421  VYQDEKQRKD KVFQGNFDND THRKNVIDPP IYARHIRILP WSWYGRITLR SELLGCTEEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EDIL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
175 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 175 nTPM
  • blood vessel: 82 nTPM
  • hippocampal formation: 81 nTPM
  • midbrain: 78 nTPM
  • cerebral cortex: 74 nTPM
  • basal ganglia: 54 nTPM

Single-cell type

  • oligodendrocytes: 2,349 nCPM
  • retinal bipolar cells: 1,094 nCPM
  • oligodendrocyte progenitor cells: 766 nCPM
  • brain excitatory neurons: 476 nCPM
  • retinal amacrine cells: 423 nCPM
  • pancreatic islet cells: 323 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 519 nTPM
  • basal ganglia: 260 nTPM
  • medulla oblongata: 253 nTPM
  • spinal cord: 209 nTPM
  • pons: 209 nTPM
  • cerebellum: 198 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EDIL3.

Disease | ImmuneIEDB

Conditions an epitope on EDIL3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
gnomAD missense Z
1.16
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EDIL3 as an antibody target. Whether an autoantibody or antibody against EDIL3 could matter depends on whether native EDIL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EDIL3 is annotated as secreted, so native EDIL3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EDIL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EDIL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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