Seroatlas · Human Serome Atlas

PROZ

Vitamin K-dependent protein Z

Also known as: PROZ_HUMAN, PZ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P22891
Gene
PROZ
Ensembl
ENSG00000126231
Chromosome
13
Canonical length
400 aa
Protein class
Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>P22891|PROZ
     1  MAGCVPLLQG LVLVLALHRV EPSVFLPASK ANDVLVRWKR AGSYLLEELF EGNLEKECYE
    61  EICVYEEARE VFENEVVTDE FWRRYKGGSP CISQPCLHNG SCQDSIWGYT CTCSPGYEGS
   121  NCELAKNECH PERTDGCQHF CLPGQESYTC SCAQGYRLGE DHKQCVPHDQ CACGVLTSEK
   181  RAPDLQDLPW QVKLTNSEGK DFCGGVIIRE NFVLTTAKCS LLHRNITVKT YFNRTSQDPL
   241  MIKITHVHVH MRYDADAGEN DLSLLELEWP IQCPGAGLPV CTPEKDFAEH LLIPRTRGLL
   301  SGWARNGTDL GNSLTTRPVT LVEGEECGQV LNVTVTTRTY CERSSVAAMH WMDGSVVTRE
   361  HRGSWFLTGV LGSQPVGGQA HMVLVTKVSR YSLWFKQIMN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
109 nTPM

Expression across tissuesHPA

Tissue

  • liver: 109 nTPM
  • kidney: 13 nTPM
  • testis: 1.6 nTPM
  • pituitary gland: 1.2 nTPM
  • cerebellum: 0.7 nTPM
  • pancreas: 0.7 nTPM

Single-cell type

  • hepatocytes: 83 nCPM
  • proximal tubule cells: 15 nCPM
  • epicardial cells: 11 nCPM
  • cardiomyocytes: 10 nCPM
  • goblet cells: 6 nCPM
  • adipocytes: 1.8 nCPM

Immune cell

  • intermediate monocyte: 0.6 nTPM
  • T-reg: 0.3 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 2.7 nTPM
  • cerebral cortex: 1.4 nTPM
  • basal ganglia: 1.3 nTPM
  • choroid plexus: 1.2 nTPM
  • hypothalamus: 1 nTPM
  • hippocampal formation: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.73
gnomAD pLI
0
gnomAD missense Z
-0.06
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PROZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROZ as an antibody target. Whether an autoantibody or antibody against PROZ could matter depends on whether native PROZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROZ is annotated as secreted, so native PROZ circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PROZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PROZ. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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