Seroatlas · Human Serome Atlas

GAS6

Growth arrest-specific protein 6

Also known as: AXLLG, AXSF, DKFZp666G247, FLJ34709, GAS6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14393
Gene: GAS6
Ensembl: ENSG00000183087
Chromosome: 13
Canonical length: 678 aa
Protein class: Predicted secreted proteins
Subcellular location: Centriolar satellite,Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

Canonical amino-acid sequenceUniProt

678 residues, UniProt reviewed canonical sequence.

>Q14393|GAS6
     1  MAPSLSPGPA ALRRAPQLLL LLLAAECALA ALLPAREATQ FLRPRQRRAF QVFEEAKQGH
    61  LERECVEELC SREEAREVFE NDPETDYFYP RYLDCINKYG SPYTKNSGFA TCVQNLPDQC
   121  TPNPCDRKGT QACQDLMGNF FCLCKAGWGG RLCDKDVNEC SQENGGCLQI CHNKPGSFHC
   181  SCHSGFELSS DGRTCQDIDE CADSEACGEA RCKNLPGSYS CLCDEGFAYS SQEKACRDVD
   241  ECLQGRCEQV CVNSPGSYTC HCDGRGGLKL SQDMDTCEDI LPCVPFSVAK SVKSLYLGRM
   301  FSGTPVIRLR FKRLQPTRLV AEFDFRTFDP EGILLFAGGH QDSTWIVLAL RAGRLELQLR
   361  YNGVGRVTSS GPVINHGMWQ TISVEELARN LVIKVNRDAV MKIAVAGDLF QPERGLYHLN
   421  LTVGGIPFHE KDLVQPINPR LDGCMRSWNW LNGEDTTIQE TVKVNTRMQC FSVTERGSFY
   481  PGSGFAFYSL DYMRTPLDVG TESTWEVEVV AHIRPAADTG VLFALWAPDL RAVPLSVALV
   541  DYHSTKKLKK QLVVLAVEHT ALALMEIKVC DGQEHVVTVS LRDGEATLEV DGTRGQSEVS
   601  AAQLQERLAV LERHLRSPVL TFAGGLPDVP VTSAPVTAFY RGCMTLEVNR RLLDLDEAAY
   661  KHSDITAHSC PPVEPAAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 838 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 838 nTPM
cervix: 195 nTPM
endometrium: 164 nTPM
vagina: 161 nTPM
heart muscle: 158 nTPM
fallopian tube: 151 nTPM

Single-cell type

fallopian secretory cells: 501 nCPM
alveolar cells type 1: 372 nCPM
breast myoepithelial cells: 333 nCPM
smooth muscle cells: 307 nCPM
granulosa cells: 305 nCPM
retinal horizontal cells: 248 nCPM

Immune cell

plasmacytoid DC: 71 nTPM
myeloid DC: 11 nTPM
classical monocyte: 1.4 nTPM
total PBMC: 1.4 nTPM
intermediate monocyte: 1.1 nTPM
non-classical monocyte: 0.3 nTPM

Brain region

choroid plexus: 113 nTPM
pons: 70 nTPM
medulla oblongata: 67 nTPM
midbrain: 66 nTPM
hypothalamus: 61 nTPM
thalamus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.03
gnomAD missense Z: 1.19
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAS6 as an antibody target. Whether an autoantibody or antibody against GAS6 could matter depends on whether native GAS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAS6 is annotated as secreted, so native GAS6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GAS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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