Seroatlas · Human Serome Atlas

NOTCH2NLB

Notch homolog 2 N-terminal-like protein B

Also known as: NT2NB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPK3
Gene: NOTCH2NLB
Ensembl: ENSG00000286019
Chromosome: 1
Canonical length: 275 aa
Protein class: Disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Enables Notch binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>P0DPK3|NOTCH2NLB
     1  MPALRPALLW ALLALWLCCA TPAHALQCRD GYEPCVNEGM CVTYHNGTGY CKCPEGFLGE
    61  YCQHRDPCEK NRCQNGGTCV AQAMLGKATC RCASGFTGED CQYSTSHPCF VSRPCLNGGT
   121  CHMLSRDTYE CTCQVGFTGK ECQWTDACLS HPCANGSTCT TVANQFSCKC LTGFTGQKCE
   181  TDVNECDIPG HCQHGGICLN LPGSYQCQCL QGFTGQYCDS LYVPCAPSPC VNGGTCRQTG
   241  DFTFECNCLP ETVRRGTELW ERDREVWNGK EHDEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOTCH2NLB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
skin: 13 nTPM
esophagus: 10 nTPM
blood vessel: 9.9 nTPM
vagina: 9.5 nTPM
cervix: 8.8 nTPM

Single-cell type

ocular epithelial cells: 0.2 nCPM
urothelial cells: 0.2 nCPM
epididymal efferent duct absorptive cells: 0.1 nCPM
esophageal apical cells: 0.1 nCPM
fallopian tube ciliated cells: 0.1 nCPM
innate lymphoid cells: 0.1 nCPM

Immune cell

eosinophil: 3.9 nTPM
non-classical monocyte: 3.7 nTPM
naive B-cell: 3 nTPM
neutrophil: 3 nTPM
memory B-cell: 2.9 nTPM
plasmacytoid DC: 2.7 nTPM

Brain region

choroid plexus: 13 nTPM
hippocampal formation: 12 nTPM
medulla oblongata: 12 nTPM
cerebral cortex: 11 nTPM
thalamus: 10 nTPM
hypothalamus: 9.9 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOTCH2NLB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOTCH2NLB as an antibody target. Whether an autoantibody or antibody against NOTCH2NLB could matter depends on whether native NOTCH2NLB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOTCH2NLB is annotated as secreted, so native NOTCH2NLB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NOTCH2NLB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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