NELL1

Protein identityUniProt · HPA

UniProt accession

Q92832

Gene

NELL1

Ensembl

ENSG00000165973

Chromosome

11

Canonical length

810 aa

Protein class

Predicted secreted proteins

Secretome location

Secreted in other tissues

Quaternary structure

Homotrimer

OverviewNCBI Gene

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

810 residues, UniProt reviewed canonical sequence.

>Q92832|NELL1
     1  MPMDLILVVW FCVCTARTVV GFGMDPDLQM DIVTELDLVN TTLGVAQVSG MHNASKAFLF
    61  QDIEREIHAA PHVSEKLIQL FRNKSEFTIL ATVQQKPSTS GVILSIRELE HSYFELESSG
   121  LRDEIRYHYI HNGKPRTEAL PYRMADGQWH KVALSVSASH LLLHVDCNRI YERVIDPPDT
   181  NLPPGINLWL GQRNQKHGLF KGIIQDGKII FMPNGYITQC PNLNHTCPTC SDFLSLVQGI
   241  MDLQELLAKM TAKLNYAETR LSQLENCHCE KTCQVSGLLY RDQDSWVDGD HCRNCTCKSG
   301  AVECRRMSCP PLNCSPDSLP VHIAGQCCKV CRPKCIYGGK VLAEGQRILT KSCRECRGGV
   361  LVKITEMCPP LNCSEKDHIL PENQCCRVCR GHNFCAEGPK CGENSECKNW NTKATCECKS
   421  GYISVQGDSA YCEDIDECAA KMHYCHANTV CVNLPGLYRC DCVPGYIRVD DFSCTEHDEC
   481  GSGQHNCDEN AICTNTVQGH SCTCKPGYVG NGTICRAFCE EGCRYGGTCV APNKCVCPSG
   541  FTGSHCEKDI DECSEGIIEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC
   601  ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWTLK EDRCSVCSCK
   661  DGKIFCRRTA CDCQNPSADL FCCPECDTRV TSQCLDQNGH KLYRSGDNWT HSCQQCRCLE
   721  GEVDCWPLTC PNLSCEYTAI LEGECCPRCV SDPCLADNIT YDIRKTCLDS YGVSRLSGSV
   781  WTMAGSPCTT CKCKNGRVCC SVDFECLQNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NELL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

16 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for NELL1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.75

gnomAD pLI

0

gnomAD missense Z

-0.01

DepMap mean gene effect

0.17

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• negative regulation of osteoblast proliferation
• negative regulation of protein catabolic process
• nervous system development
• positive regulation of bone mineralization
• positive regulation of ossification
• positive regulation of osteoblast differentiation
• regulation of gene expression
• regulation of osteoblast differentiation

Molecular functions

• calcium ion binding
• heparin binding
• protein kinase C binding

Cellular components

• cytoplasm
• extracellular space
• nuclear envelope
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• EGF-type aspartate/asparagine hydroxylation site
• EGF-like domain
• VWFC domain
• Laminin G domain
• EGF-like calcium-binding domain
• Growth factor receptor cysteine-rich domain superfamily
• Concanavalin A-like lectin/glucanase domain superfamily
• EGF-like calcium-binding, conserved site
• NELL2-like, EGF domain
• Thrombospondin-like, N-terminal domain
• NOTCH1, EGF-like calcium-binding domain
• Protein kinase C-binding NELL
• von Willebrand factor type C domain
• Laminin G domain
• Calcium-binding EGF domain
• EGF domain

KeywordsUniProt

• Calcium
• Cytoplasm
• Differentiation
• Disulfide bond
• EGF-like domain
• Glycoprotein
• Nucleus
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of NELL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATRAID
• ROBO3