Seroatlas · Human Serome Atlas

SCUBE2

Signal peptide, CUB and EGF-like domain-containing protein 2

Also known as: Cegb1, Cegf1, FLJ16792, SCUB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQ36
Gene
SCUBE2
Ensembl
ENSG00000175356
Chromosome
11
Canonical length
999 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homooligomer

OverviewNCBI Gene

Predicted to enable calcium ion binding activity; hedgehog family protein binding activity; and lipid binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; positive regulation of chondrocyte proliferation; and positive regulation of osteoblast differentiation. Predicted to be located in extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

999 residues, UniProt reviewed canonical sequence.

>Q9NQ36|SCUBE2
     1  MGVAGRNRPG AAWAVLLLLL LLPPLLLLAG AVPPGRGRAA GPQEDVDECA QGLDDCHADA
    61  LCQNTPTSYK CSCKPGYQGE GRQCEDIDEC GNELNGGCVH DCLNIPGNYR CTCFDGFMLA
   121  HDGHNCLDVD ECLENNGGCQ HTCVNVMGSY ECCCKEGFFL SDNQHTCIHR SEEGLSCMNK
   181  DHGCSHICKE APRGSVACEC RPGFELAKNQ RDCILTCNHG NGGCQHSCDD TADGPECSCH
   241  PQYKMHTDGR SCLEREDTVL EVTESNTTSV VDGDKRVKRR LLMETCAVNN GGCDRTCKDT
   301  STGVHCSCPV GFTLQLDGKT CKDIDECQTR NGGCDHFCKN IVGSFDCGCK KGFKLLTDEK
   361  SCQDVDECSL DRTCDHSCIN HPGTFACACN RGYTLYGFTH CGDTNECSIN NGGCQQVCVN
   421  TVGSYECQCH PGYKLHWNKK DCVEVKGLLP TSVSPRVSLH CGKSGGGDGC FLRCHSGIHL
   481  SSDVTTIRTS VTFKLNEGKC SLKNAELFPE GLRPALPEKH SSVKESFRYV NLTCSSGKQV
   541  PGAPGRPSTP KEMFITVEFE LETNQKEVTA SCDLSCIVKR TEKRLRKAIR TLRKAVHREQ
   601  FHLQLSGMNL DVAKKPPRTS ERQAESCGVG QGHAENQCVS CRAGTYYDGA RERCILCPNG
   661  TFQNEEGQMT CEPCPRPGNS GALKTPEAWN MSECGGLCQP GEYSADGFAP CQLCALGTFQ
   721  PEAGRTSCFP CGGGLATKHQ GATSFQDCET RVQCSPGHFY NTTTHRCIRC PVGTYQPEFG
   781  KNNCVSCPGN TTTDFDGSTN ITQCKNRRCG GELGDFTGYI ESPNYPGNYP ANTECTWTIN
   841  PPPKRRILIV VPEIFLPIED DCGDYLVMRK TSSSNSVTTY ETCQTYERPI AFTSRSKKLW
   901  IQFKSNEGNS ARGFQVPYVT YDEDYQELIE DIVRDGRLYA SENHQEILKD KKLIKALFDV
   961  LAHPQNYFKY TAQESREMFP RSFIRLLRSK VSRFLRPYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCUBE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 46 nTPM
  • prostate: 31 nTPM
  • breast: 30 nTPM
  • urinary bladder: 27 nTPM
  • placenta: 21 nTPM
  • pancreas: 20 nTPM

Single-cell type

  • prostatic club cells: 207 nCPM
  • urothelial cells: 175 nCPM
  • breast hormone-responsive cells: 140 nCPM
  • somatotrophs: 114 nCPM
  • epididymal basal cells: 104 nCPM
  • basal prostatic cells: 102 nCPM

Immune cell

  • non-classical monocyte: 1 nTPM
  • classical monocyte: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 31 nTPM
  • spinal cord: 14 nTPM
  • white matter: 13 nTPM
  • hypothalamus: 13 nTPM
  • hippocampal formation: 11 nTPM
  • pons: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCUBE2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 164 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.98
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCUBE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCUBE2 as an antibody target. Whether an autoantibody or antibody against SCUBE2 could matter depends on whether native SCUBE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCUBE2 is annotated at the cell surface, where native SCUBE2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCUBE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCUBE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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