Seroatlas · Human Serome Atlas

ADGRE4P

Putative adhesion G protein-coupled receptor E4P

Also known as: AGRE4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SQ3
Gene: ADGRE4P
Canonical length: 457 aa

OverviewNCBI Gene

No narrative summary is available for ADGRE4P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

457 residues, UniProt reviewed canonical sequence.

>Q86SQ3|ADGRE4P
     1  MGSRFLLVLL SGASCPPCPK YASCHNSTHC TCEDGFRARS GRTYFHDSSE KCEDINECET
    61  GLAKCKYKAY CRNKVGGYIC SCLVKYTLFN FLAGIIDYDH PDCYENNSQG TTQSNVDIWV
   121  SGVKPGFGKQ LPGDKRTKHI CVYWEGSEGG WSTEGCSHVH SNGSYTKCKC FHLSSFAVLV
   181  ALAPKEDPVL TVITQVGLTI SLLCLFLAIL TFLLCRPIQN TSTSLHLELS LCLFLAHLLF
   241  LTGINRTEPE VLCSIIAGLL HFLYLACFTW MLLEGLHLFL TVRNLKVANY TSTGRFKKRF
   301  MYPVGYGIPA VIIAVSAIVG PQNYGTFTCW LKLDKGFIWS FMGPVAVIIL INLVFYFQVL
   361  WILRSKLSSL NKEVSTIQDT RVMTFKAISQ LFILGCSWGL GFFMVEEVGK TIGSIIAYSF
   421  TIINTLQGVL LFVVHCLLNR QVRLIILSVI SLVPKSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRE4P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRE4P as an antibody target. Whether an autoantibody or antibody against ADGRE4P could matter depends on whether native ADGRE4P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRE4P is annotated at the cell surface, where native ADGRE4P is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRE4P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...