Seroatlas · Human Serome Atlas

SCUBE1

Signal peptide, CUB and EGF-like domain-containing protein 1

Also known as: SCUB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IWY4
Gene
SCUBE1
Ensembl
ENSG00000159307
Chromosome
22
Canonical length
988 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

988 residues, UniProt reviewed canonical sequence.

>Q8IWY4|SCUBE1
     1  MGAAAVRWHL CVLLALGTRG RLAGGSGLPG SVDVDECSEG TDDCHIDAIC QNTPKSYKCL
    61  CKPGYKGEGK QCEDIDECEN DYYNGGCVHE CINIPGNYRC TCFDGFMLAH DGHNCLDVDE
   121  CQDNNGGCQQ ICVNAMGSYE CQCHSGFFLS DNQHTCIHRS NEGMNCMNKD HGCAHICRET
   181  PKGGVACDCR PGFDLAQNQK DCTLTCNYGN GGCQHSCEDT DTGPTCGCHQ KYALHSDGRT
   241  CIETCAVNNG GCDRTCKDTA TGVRCSCPVG FTLQPDGKTC KDINECLVNN GGCDHFCRNT
   301  VGSFECGCRK GYKLLTDERT CQDIDECSFE RTCDHICINS PGSFQCLCHR GYILYGTTHC
   361  GDVDECSMSN GSCDQGCVNT KGSYECVCPP GRRLHWNGKD CVETGKCLSR AKTSPRAQLS
   421  CSKAGGVESC FLSCPAHTLF VPDSENSYVL SCGVPGPQGK ALQKRNGTSS GLGPSCSDAP
   481  TTPIKQKARF KIRDAKCHLR PHSQARAKET ARQPLLDHCH VTFVTLKCDS SKKRRRGRKS
   541  PSKEVSHITA EFEIETKMEE ASDTCEADCL RKRAEQSLQA AIKTLRKSIG RQQFYVQVSG
   601  TEYEVAQRPA KALEGQGACG AGQVLQDSKC VACGPGTHFG GELGQCVSCM PGTYQDMEGQ
   661  LSCTPCPSSD GLGLPGARNV SECGGQCSPG FFSADGFKPC QACPVGTYQP EPGRTGCFPC
   721  GGGLLTKHEG TTSFQDCEAK VHCSPGHHYN TTTHRCIRCP VGTYQPEFGQ NHCITCPGNT
   781  STDFDGSTNV THCKNQHCGG ELGDYTGYIE SPNYPGDYPA NAECVWHIAP PPKRRILIVV
   841  PEIFLPIEDE CGDVLVMRKS ASPTSITTYE TCQTYERPIA FTSRSRKLWI QFKSNEGNSG
   901  KGFQVPYVTY DEDYQQLIED IVRDGRLYAS ENHQEILKDK KLIKALFDVL AHPQNYFKYT
   961  AQESKEMFPR SFIKLLRSKV SRFLRPYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCUBE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 25 nTPM
  • blood vessel: 7.5 nTPM
  • skeletal muscle: 7.3 nTPM
  • lung: 6 nTPM
  • stomach: 5.9 nTPM
  • testis: 5.8 nTPM

Single-cell type

  • peritubular myoid cells: 68 nCPM
  • extravillous trophoblasts: 54 nCPM
  • ovarian stromal cells: 35 nCPM
  • pituitary stem cells: 34 nCPM
  • alveolar cells type 1: 26 nCPM
  • leydig cells: 21 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 20 nTPM
  • pons: 15 nTPM
  • hypothalamus: 7.8 nTPM
  • choroid plexus: 6.9 nTPM
  • medulla oblongata: 4.2 nTPM
  • cerebral cortex: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.96
gnomAD missense Z
1.98
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCUBE1 as an antibody target. Whether an autoantibody or antibody against SCUBE1 could matter depends on whether native SCUBE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCUBE1 is annotated at the cell surface, where native SCUBE1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCUBE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCUBE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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