Seroatlas · Human Serome Atlas

PROC

Vitamin K-dependent protein C

Also known as: PROC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P04070
Gene
PROC
Ensembl
ENSG00000115718
Chromosome
2
Canonical length
461 aa
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>P04070|PROC
     1  MWQLTSLLLF VATWGISGTP APLDSVFSSS ERAHQVLRIR KRANSFLEEL RHSSLERECI
    61  EEICDFEEAK EIFQNVDDTL AFWSKHVDGD QCLVLPLEHP CASLCCGHGT CIDGIGSFSC
   121  DCRSGWEGRF CQREVSFLNC SLDNGGCTHY CLEEVGWRRC SCAPGYKLGD DLLQCHPAVK
   181  FPCGRPWKRM EKKRSHLKRD TEDQEDQVDP RLIDGKMTRR GDSPWQVVLL DSKKKLACGA
   241  VLIHPSWVLT AAHCMDESKK LLVRLGEYDL RRWEKWELDL DIKEVFVHPN YSKSTTDNDI
   301  ALLHLAQPAT LSQTIVPICL PDSGLAEREL NQAGQETLVT GWGYHSSREK EAKRNRTFVL
   361  NFIKIPVVPH NECSEVMSNM VSENMLCAGI LGDRQDACEG DSGGPMVASF HGTWFLVGLV
   421  SWGEGCGLLH NYGVYTKVSR YLDWIHGHIR DKEAPQKSWA P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
584 nTPM

Expression across tissuesHPA

Tissue

  • liver: 584 nTPM
  • kidney: 14 nTPM
  • stomach: 2.5 nTPM
  • hypothalamus: 1.5 nTPM
  • amygdala: 1.4 nTPM
  • hippocampal formation: 1.4 nTPM

Single-cell type

  • hepatocytes: 520 nCPM
  • cholangiocytes: 54 nCPM
  • pdcs: 51 nCPM
  • proximal tubule cells: 26 nCPM
  • tuft cells: 23 nCPM
  • goblet cells: 20 nCPM

Immune cell

  • plasmacytoid DC: 60 nTPM
  • neutrophil: 6.3 nTPM
  • memory B-cell: 1.2 nTPM
  • myeloid DC: 0.3 nTPM
  • total PBMC: 0.3 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • medulla oblongata: 4.6 nTPM
  • pons: 4.4 nTPM
  • cerebral cortex: 3.5 nTPM
  • hypothalamus: 3.5 nTPM
  • white matter: 3.3 nTPM
  • thalamus: 3.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PROC.

Disease | AllUniProt

Conditions PROC is implicated in, by any mechanism.

  • Thrombophilia due to protein C deficiency, autosomal dominant (THPH3) MIM:176860
  • Thrombophilia due to protein C deficiency, autosomal recessive (THPH4) MIM:612304

Disease | GeneticClinVar

111 pathogenic / likely-pathogenic of 480 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.88
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROC as an antibody target. Whether an autoantibody or antibody against PROC could matter depends on whether native PROC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROC is annotated as secreted, so native PROC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PROC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PROC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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