Seroatlas · Human Serome Atlas

ADGRE1

Adhesion G protein-coupled receptor E1

Also known as: AGRE1_HUMAN, EMR1, TM7LN3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14246
Gene: ADGRE1
Ensembl: ENSG00000174837
Chromosome: 19
Canonical length: 886 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

886 residues, UniProt reviewed canonical sequence.

>Q14246|ADGRE1
     1  MRGFNLLLFW GCCVMHSWEG HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCACKQ
    61  GFLSSNGQNH FKDPGVRCKD IDECSQSPQP CGPNSSCKNL SGRYKCSCLD GFSSPTGNDW
   121  VPGKPGNFSC TDINECLTSS VCPEHSDCVN SMGSYSCSCQ VGFISRNSTC EDVDECADPR
   181  ACPEHATCNN TVGNYSCFCN PGFESSSGHL SFQGLKASCE DIDECTEMCP INSTCTNTPG
   241  SYFCTCHPGF APSNGQLNFT DQGVECRDID ECRQDPSTCG PNSICTNALG SYSCGCIAGF
   301  HPNPEGSQKD GNFSCQRVLF KCKEDVIPDN KQIQQCQEGT AVKPAYVSFC AQINNIFSVL
   361  DKVCENKTTV VSLKNTTESF VPVLKQISTW TKFTKEETSS LATVFLESVE SMTLASFWKP
   421  SANITPAVRT EYLDIESKVI NKECSEENVT LDLVAKGDKM KIGCSTIEES ESTETTGVAF
   481  VSFVGMESVL NERFFKDHQA PLTTSEIKLK MNSRVVGGIM TGEKKDGFSD PIIYTLENIQ
   541  PKQKFERPIC VSWSTDVKGG RWTSFGCVIL EASETYTICS CNQMANLAVI MASGELTMDF
   601  SLYIISHVGI IISLVCLVLA IATFLLCRSI RNHNTYLHLH LCVCLLLAKT LFLAGIHKTD
   661  NKMGCAIIAG FLHYLFLACF FWMLVEAVIL FLMVRNLKVV NYFSSRNIKM LHICAFGYGL
   721  PMLVVVISAS VQPQGYGMHN RCWLNTETGF IWSFLGPVCT VIVINSLLLT WTLWILRQRL
   781  SSVNAEVSTL KDTRLLTFKA FAQLFILGCS WVLGIFQIGP VAGVMAYLFT IINSLQGAFI
   841  FLIHCLLNGQ VREEYKRWIT GKTKPSSQSQ TSRILLSSMP SASKTG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

spleen: 14 nTPM
appendix: 6.9 nTPM
bone marrow: 6.4 nTPM
lung: 4.4 nTPM
urinary bladder: 3.8 nTPM
thymus: 3.2 nTPM

Single-cell type

neutrophils: 74 nCPM
kupffer cells: 48 nCPM
neutrophil progenitors: 48 nCPM
monocytes: 42 nCPM
platelets: 18 nCPM
early spermatids: 18 nCPM

Immune cell

eosinophil: 326 nTPM
basophil: 167 nTPM
non-classical monocyte: 105 nTPM
intermediate monocyte: 59 nTPM
classical monocyte: 21 nTPM
myeloid DC: 12 nTPM

Brain region

medulla oblongata: 2.4 nTPM
cerebral cortex: 1.5 nTPM
pons: 1.5 nTPM
white matter: 1.4 nTPM
hypothalamus: 1.1 nTPM
spinal cord: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRE1 as an antibody target. Whether an autoantibody or antibody against ADGRE1 could matter depends on whether native ADGRE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRE1 is annotated at the cell surface, where native ADGRE1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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