Seroatlas · Human Serome Atlas

DLL1

Delta-like protein 1

Also known as: DLL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00548
Gene
DLL1
Ensembl
ENSG00000198719
Chromosome
6
Canonical length
723 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

723 residues, UniProt reviewed canonical sequence.

>O00548|DLL1
     1  MGSRCALALA VLSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGAG PPPCACRTFF
    61  RVCLKHYQAS VSPEPPCTYG SAVTPVLGVD SFSLPDGGGA DSAFSNPIRF PFGFTWPGTF
   121  SLIIEALHTD SPDDLATENP ERLISRLATQ RHLTVGEEWS QDLHSSGRTD LKYSYRFVCD
   181  EHYYGEGCSV FCRPRDDAFG HFTCGERGEK VCNPGWKGPY CTEPICLPGC DEQHGFCDKP
   241  GECKCRVGWQ GRYCDECIRY PGCLHGTCQQ PWQCNCQEGW GGLFCNQDLN YCTHHKPCKN
   301  GATCTNTGQG SYTCSCRPGY TGATCELGID ECDPSPCKNG GSCTDLENSY SCTCPPGFYG
   361  KICELSAMTC ADGPCFNGGR CSDSPDGGYS CRCPVGYSGF NCEKKIDYCS SSPCSNGAKC
   421  VDLGDAYLCR CQAGFSGRHC DDNVDDCASS PCANGGTCRD GVNDFSCTCP PGYTGRNCSA
   481  PVSRCEHAPC HNGATCHERG HRYVCECARG YGGPNCQFLL PELPPGPAVV DLTEKLEGQG
   541  GPFPWVAVCA GVILVLMLLL GCAAVVVCVR LRLQKHRPPA DPCRGETETM NNLANCQREK
   601  DISVSIIGAT QIKNTNKKAD FHGDHSADKN GFKARYPAVD YNLVQDLKGD DTAVRDAHSK
   661  RDTKCQPQGS SGEEKGTPTT LRGGEASERK RPDSGCSTSK DTKYQSVYVI SEEKDECVIA
   721  TEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 43 nTPM
  • prostate: 23 nTPM
  • skin: 21 nTPM
  • vagina: 18 nTPM
  • esophagus: 17 nTPM
  • adipose tissue: 16 nTPM

Single-cell type

  • ependymal cells: 61 nCPM
  • renal collecting duct intercalated cells: 48 nCPM
  • oligodendrocyte progenitor cells: 37 nCPM
  • oligodendrocytes: 26 nCPM
  • bergmann glia: 24 nCPM
  • astrocytes: 23 nCPM

Immune cell

  • NK-cell: 3.3 nTPM
  • non-classical monocyte: 0.4 nTPM
  • intermediate monocyte: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • white matter: 32 nTPM
  • basal ganglia: 23 nTPM
  • medulla oblongata: 22 nTPM
  • midbrain: 20 nTPM
  • pons: 19 nTPM
  • cerebral cortex: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DLL1.

Disease | AllUniProt

Conditions DLL1 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with non-specific brain abnormalities and with or without seizures (NEDBAS) MIM:618709

Disease | GeneticClinVar

64 pathogenic / likely-pathogenic of 703 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.1
gnomAD pLI
1
gnomAD missense Z
1.82
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLL1 as an antibody target. Whether an autoantibody or antibody against DLL1 could matter depends on whether native DLL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLL1 is annotated at the cell surface, where native DLL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DLL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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