Seroatlas · Human Serome Atlas

NOTCH2NLC

Notch homolog 2 N-terminal-like protein C

Also known as: NT2NC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPK4
Gene: NOTCH2NLC
Ensembl: ENSG00000286219
Chromosome: 1
Canonical length: 293 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Enables Notch binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Located in extracellular region. Implicated in essential tremor 6; neuronal intranuclear inclusion disease; and oculopharyngodistal myopathy 3. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>P0DPK4|NOTCH2NLC
     1  MWICPGGGGG GGGGGGGGDR EDARPAPLCC GRCWRSGCAA RPPRMCRDGY EPCVNEGMCV
    61  TYHNGTGYCK CPEGFLGEYC QHRDPCEKNR CQNGGTCVAQ AMLGKATCRC ASGFTGEDCQ
   121  YSTSHPCFVS RPCLNGGTCH MLSRDTYECT CQVGFTGKEC QWTDACLSHP CANGSTCTTV
   181  ANQFSCKCLT GFTGQKCETD VNECDIPGHC QHGGTCLNLP GSYQCQCLQG FTGQYCDSLY
   241  VPCAPSPCVN GGTCRQTGDF TFECNCLPET VRRGTELWER DREVWNGKEH DEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOTCH2NLC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

retina: 10 nTPM
skin: 9.6 nTPM
blood vessel: 6.4 nTPM
epididymis: 6.3 nTPM
vagina: 5.5 nTPM
cervix: 5.4 nTPM

Single-cell type

leydig cells: 0.4 nCPM
mast cells: 0.3 nCPM
prostatic club cells: 0.3 nCPM
suprabasal keratinocytes: 0.3 nCPM
cdc: 0.2 nCPM
colonocytes: 0.1 nCPM

Immune cell

naive CD8 T-cell: 9.2 nTPM
naive CD4 T-cell: 8.5 nTPM
non-classical monocyte: 7.9 nTPM
basophil: 7.1 nTPM
classical monocyte: 6.2 nTPM
memory CD4 T-cell: 5.4 nTPM

Brain region

choroid plexus: 20 nTPM
cerebral cortex: 19 nTPM
thalamus: 14 nTPM
medulla oblongata: 12 nTPM
amygdala: 11 nTPM
midbrain: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NOTCH2NLC.

Disease | AllUniProt

Conditions NOTCH2NLC is implicated in, by any mechanism.

Neuronal intranuclear inclusion disease (NIID) MIM:603472
Tremor, hereditary essential 6 (ETM6) MIM:618866
Oculopharyngodistal myopathy 3 (OPDM3) MIM:619473

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOTCH2NLC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOTCH2NLC as an antibody target. Whether an autoantibody or antibody against NOTCH2NLC could matter depends on whether native NOTCH2NLC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOTCH2NLC is annotated as secreted, so native NOTCH2NLC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NOTCH2NLC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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