LRP1B

Protein identityUniProt · HPA

UniProt accession

Q9NZR2

Gene

LRP1B

Ensembl

ENSG00000168702

Chromosome

2

Canonical length

4599 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Vesicles

OverviewNCBI Gene

This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

4599 residues, UniProt reviewed canonical sequence.

>Q9NZR2|LRP1B
     1  MSEFLLALLT LSGLLPIARV LTVGADRDQQ LCDPGEFLCH DHVTCVSQSW LCDGDPDCPD
    61  DSDESLDTCP EEVEIKCPLN HIACLGTNKC VHLSQLCNGV LDCPDGYDEG VHCQELLSNC
   121  QQLNCQYKCT MVRNSTRCYC EDGFEITEDG RSCKDQDECA VYGTCSQTCR NTHGSYTCSC
   181  VEGYLMQPDN RSCKAKIEPT DRPPILLIAN FETIEVFYLN GSKMATLSSV NGNEIHTLDF
   241  IYNEDMICWI ESRESSNQLK CIQITKAGGL TDEWTINILQ SFHNVQQMAI DWLTRNLYFV
   301  DHVGDRIFVC NSNGSVCVTL IDLELHNPKA IAVDPIAGKL FFTDYGNVAK VERCDMDGMN
   361  RTRIIDSKTE QPAALALDLV NKLVYWVDLY LDYVGVVDYQ GKNRHTVIQG RQVRHLYGIT
   421  VFEDYLYATN SDNYNIVRIN RFNGTDIHSL IKIENAWGIR IYQKRTQPTV RSHACEVDPY
   481  GMPGGCSHIC LLSSSYKTRT CRCRTGFNLG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL
   541  NTKIADEYMI PIENLVNPRA LDFHAETNYI YFADTTSFLI GRQKIDGTER ETILKDDLDN
   601  VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGEMSHPRGI VVDPVNGWMY
   661  WTDWEEDEID DSVGRIEKAW MDGFNRQIFV TSKMLWPNGL TLDFHTNTLY WCDAYYDHIE
   721  KVFLNGTHRK IVYSGRELNH PFGLSHHGNY VFWTDYMNGS IFQLDLITSE VTLLRHERPP
   781  LFGLQIYDPR KQQGDNMCRV NNGGCSTLCL AIPGGRVCAC ADNQLLDENG TTCTFNPGEA
   841  LPHICKAGEF RCKNRHCIQA RWKCDGDDDC LDGSDEDSVN CFNHSCPDDQ FKCQNNRCIP
   901  KRWLCDGAND CGSNEDESNQ TCTARTCQVD QFSCGNGRCI PRAWLCDRED DCGDQTDEMA
   961  SCEFPTCEPL TQFVCKSGRC ISSKWHCDSD DDCGDGSDEV GCVHSCFDNQ FRCSSGRCIP
  1021  GHWACDGDND CGDFSDEAQI NCTKEEIHSP AGCNGNEFQC HPDGNCVPDL WRCDGEKDCE
  1081  DGSDEKGCNG TIRLCDHKTK FSCWSTGRCI NKAWVCDGDI DCEDQSDEDD CDSFLCGPPK
  1141  HPCANDTSVC LQPEKLCNGK KDCPDGSDEG YLCDECSLNN GGCSNHCSVV PGRGIVCSCP
  1201  EGLQLNKDNK TCEIVDYCSN HLKCSQVCEQ HKHTVKCSCY EGWKLDVDGE SCTSVDPFEA
  1261  FIIFSIRHEI RRIDLHKRDY SLLVPGLRNT IALDFHFNQS LLYWTDVVED RIYRGKLSES
  1321  GGVSAIEVVV EHGLATPEGL TVDWIAGNIY WIDSNLDQIE VAKLDGSLRT TLIAGAMEHP
  1381  RAIALDPRYG ILFWTDWDAN FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFEKRIV
  1441  WTDARSDAIY SALYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLSKANKWTG
  1501  QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANDGKGPC SHMCLINHNR SAACACPHLM
  1561  KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYFNFITAF TVPDIDDVTV IDFDASEERL
  1621  YWTDIKTQTI KRAFINGTGL ETVISRDIQS IRGLAVDWVS RNLYWISSEF DETQINVARL
  1681  DGSLKTSIIH GIDKPQCLAA HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI
  1741  DYVENKLYWI SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL
  1801  GTCSKRDGRN PTILRNKTSG VVHMKVYDKE AQQGSNSCQL NNGGCSQLCL PTSETTRTCM
  1861  CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPSDKM DALMPISGTS FAVGIDFHAE
  1921  NDTIYWTDMG FNKISRAKRD QTWKEDIITN GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA
  1981  RLNGSFRYVI ISQGLDQPRS IAVHPEKGLL FWTEWGQMPC IGKARLDGSE KVVLVSMGIA
  2041  WPNGISIDYE ENKLYWCDAR TDKIERIDLE TGGNREMVLS GSNVDMFSVA VFGAYIYWSD
  2101  RAHANGSVRR GHKNDATETI TMRTGLGVNL KEVKIFNRVR EKGTNVCARD NGGCKQLCLY
  2161  RGNSRRTCAC AHGYLAEDGV TCLRHEGYLL YSGRTILKSI HLSDETNLNS PIRPYENPRY
  2221  FKNVIALAFD YNQRRKGTNR IFYSDAHFGN IQLIKDNWED RQVIVENVGS VEGLAYHRAW
  2281  DTLYWTSSTT SSITRHTVDQ TRPGAFDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ
  2341  HPSIMRSTLT GKNAQVVVST DILTPNGLTI DYRAEKLYFS DGSLGKIERC EYDGSQRHVI
  2401  VKSGPGTFLS LAVYDNYIFW SDWGRRAILR SNKYTGGDTK ILRSDIPHQP MGIIAVANDT
  2461  NSCELSPCAL LNGGCHDLCL LTPNGRVNCS CRGDRILLED NRCVTKNSSC NAYSEFECGN
  2521  GECIDYQLTC DGIPHCKDKS DEKLLYCENR SCRRGFKPCY NRRCIPHGKL CDGENDCGDN
  2581  SDELDCKVST CATVEFRCAD GTCIPRSARC NQNIDCADAS DEKNCNNTDC THFYKLGVKT
  2641  TGFIRCNSTS LCVLPTWICD GSNDCGDYSD ELKCPVQNKH KCEENYFSCP SGRCILNTWI
  2701  CDGQKDCEDG RDEFHCDSSC SWNQFACSAQ KCISKHWICD GEDDCGDGLD ESDSICGAIT
  2761  CAADMFSCQG SRACVPRHWL CDGERDCPDG SDELSTAGCA PNNTCDENAF MCHNKVCIPK
  2821  QFVCDHDDDC GDGSDESPQC GYRQCGTEEF SCADGRCLLN TQWQCDGDFD CPDHSDEAPL
  2881  NPKCKSAEQS CNSSFFMCKN GRCIPSGGLC DNKDDCGDGS DERNCHINEC LSKKVSGCSQ
  2941  DCQDLPVSYK CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CLCTDGYEIQ
  3001  PDNPNGCKSL SDEEPFLILA DHHEIRKIST DGSNYTLLKQ GLNNVIAIDF DYREEFIYWI
  3061  DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN LYWSDTEKRI IEVSKLNGLY
  3121  PTILVSKRLK FPRDLSLDPQ AGYLYWIDCC EYPHIGRVGM DGTNQSVVIE TKISRPMALT
  3181  IDYVNRRLYW ADENHIEFSN MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRA
  3241  HKTSGADRLS LIYSWHAITD IQVYHSYRQP DVSKHLCMIN NGGCSHLCLL APGKTHTCAC
  3301  PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD DCPEFRCQPG
  3361  RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLSGQ FKCTKNQKCI PVNLRCNGQD
  3421  DCGDEEDERD CPENSCSPDY FQCKTTKHCI SKLWVCDEDP DCADASDEAN CDKKTCGPHE
  3481  FQCKNNNCIP DHWRCDSQND CSDNSDEENC KPQTCTLKDF LCANGDCVSS RFWCDGDFDC
  3541  ADGSDERNCE TSCSKDQFRC SNGQCIPAKW KCDGHEDCKY GEDEKSCEPA SPTCSSREYI
  3601  CASDGCISAS LKCNGEYDCA DGSDEMDCVT ECKEDQFRCK NKAHCIPIRW LCDGIHDCVD
  3661  GSDEENCERG GNICRADEFL CNNSLCKLHF WVCDGEDDCG DNSDEAPDMC VKFLCPSTRP
  3721  HRCRNNRICL QSEQMCNGID ECGDNSDEDH CGGKLTYKAR PCKKDEFACS NKKCIPMDLQ
  3781  CDRLDDCGDG SDEQGCRIAP TEYTCEDNVN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKNR
  3841  QCEDLNECLV FGTCSHQCIN VEGSYKCVCD QNFQERNNTC IAEGSEDQVL YIANDTDILG
  3901  FIYPFNYSGD HQQISHIEHN SRITGMDVYY QRDMIIWSTQ FNPGGIFYKR IHGREKRQAN
  3961  SGLICPEFKR PRDIAVDWVA GNIYWTDHSR MHWFSYYTTH WTSLRYSINV GQLNGPNCTR
  4021  LLTNMAGEPY AIAVNPKRGM MYWTVVGDHS HIEEAAMDGT LRRILVQKNL QRPTGLAVDY
  4081  FSERIYWADF ELSIIGSVLY DGSNSVVSVS SKQGLLHPHR IDIFEDYIYG AGPKNGVFRV
  4141  QKFGHGSVEY LALNIDKTKG VLISHRYKQL DLPNPCLDLA CEFLCLLNPS GATCVCPEGK
  4201  YLINGTCNDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGERCEV NHCSNYCQNG
  4261  GTCVPSVLGR PTCSCALGFT GPNCGKTVCE DFCQNGGTCI VTAGNQPYCH CQPEYTGDRC
  4321  QYYVCHHYCV NSESCTIGDD GSVECVCPTR YEGPKCEVDK CVRCHGGHCI INKDSEDIFC
  4381  NCTNGKIASS CQLCDGYCYN GGTCQLDPET NVPVCLCSTN WSGTQCERPA PKSSKSDHIS
  4441  TRSIAIIVPL VLLVTLITTL VIGLVLCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV
  4501  DHDHNDGGLL DPGFMIDPTK ARYIGGGPSA FKLPHTAPPI YLNSDLKGPL TAGPTNYSNP
  4561  VYAKLYMDGQ NCRNSLGSVD ERKELLPKKI EIGIRETVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRP1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0

Highest tissue expression

9.4 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRP1B.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 697 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Inborn genetic diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.32

gnomAD pLI

0

gnomAD missense Z

1.93

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein transport
• receptor-mediated endocytosis

Molecular functions

• calcium ion binding
• low-density lipoprotein particle receptor activity

Cellular components

• plasma membrane
• receptor complex

Protein domainsUniProt · Pfam · InterPro

• LDLR class B repeat
• EGF-type aspartate/asparagine hydroxylation site
• EGF-like domain
• EGF-like calcium-binding domain
• Low-density lipoprotein (LDL) receptor class A repeat
• Growth factor receptor cysteine-rich domain superfamily
• Six-bladed beta-propeller, TolB-like
• EGF-like calcium-binding, conserved site
• Low-density lipoprotein (LDL) receptor class A, conserved site
• Complement Clr-like EGF domain
• LDL receptor-like superfamily
• NOTCH1, EGF-like calcium-binding domain
• Low-density lipoprotein receptor-related
• EGF-like domain
• Low-density lipoprotein receptor domain class A
• Low-density lipoprotein receptor repeat class B
• Calcium-binding EGF domain
• Complement Clr-like EGF-like
• Coagulation Factor Xa inhibitory site
• Prolow-density lipoprotein receptor-related protein 1-like, beta-propeller domain
• Domain of unknown function (DUF5050)

KeywordsUniProt

• Calcium
• Disulfide bond
• EGF-like domain
• Endocytosis
• Glycoprotein
• Membrane
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of LRP1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LRPAP1