Seroatlas · Human Serome Atlas

ADGRL4

Adhesion G protein-coupled receptor L4

Also known as: AGRL4_HUMAN, ELTD1, ETL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HBW9
Gene
ADGRL4
Ensembl
ENSG00000162618
Chromosome
1
Canonical length
690 aa
Protein class
G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Biomarker of glioblastoma and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

690 residues, UniProt reviewed canonical sequence.

>Q9HBW9|ADGRL4
     1  MKRLPLLVVF STLLNCSYTQ NCTKTPCLPN AKCEIRNGIE ACYCNMGFSG NGVTICEDDN
    61  ECGNLTQSCG ENANCTNTEG SYYCMCVPGF RSSSNQDRFI TNDGTVCIEN VNANCHLDNV
   121  CIAANINKTL TKIRSIKEPV ALLQEVYRNS VTDLSPTDII TYIEILAESS SLLGYKNNTI
   181  SAKDTLSNST LTEFVKTVNN FVQRDTFVVW DKLSVNHRRT HLTKLMHTVE QATLRISQSF
   241  QKTTEFDTNS TDIALKVFFF DSYNMKHIHP HMNMDGDYIN IFPKRKAAYD SNGNVAVAFV
   301  YYKSIGPLLS SSDNFLLKPQ NYDNSEEEER VISSVISVSM SSNPPTLYEL EKITFTLSHR
   361  KVTDRYRSLC AFWNYSPDTM NGSWSSEGCE LTYSNETHTS CRCNHLTHFA ILMSSGPSIG
   421  IKDYNILTRI TQLGIIISLI CLAICIFTFW FFSEIQSTRT TIHKNLCCSL FLAELVFLVG
   481  INTNTNKLFC SIIAGLLHYF FLAAFAWMCI EGIHLYLIVV GVIYNKGFLH KNFYIFGYLS
   541  PAVVVGFSAA LGYRYYGTTK VCWLSTENNF IWSFIGPACL IILVNLLAFG VIIYKVFRHT
   601  AGLKPEVSCF ENIRSCARGA LALLFLLGTT WIFGVLHVVH ASVVTAYLFT VSNAFQGMFI
   661  FLFLCVLSRK IQEEYYRLFK NVPCCFGCLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 64 nTPM
  • breast: 57 nTPM
  • spleen: 38 nTPM
  • smooth muscle: 26 nTPM
  • urinary bladder: 22 nTPM
  • tongue: 22 nTPM

Single-cell type

  • vascular endothelial cells: 743 nCPM
  • lymphatic endothelial cells: 146 nCPM
  • late spermatids: 111 nCPM
  • late primary spermatocytes: 88 nCPM
  • early spermatids: 52 nCPM
  • fibro-adipogenic progenitors: 34 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 13 nTPM
  • pons: 12 nTPM
  • cerebral cortex: 11 nTPM
  • medulla oblongata: 11 nTPM
  • white matter: 9.9 nTPM
  • cerebellum: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRL4 as an antibody target. Whether an autoantibody or antibody against ADGRL4 could matter depends on whether native ADGRL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRL4 is annotated at the cell surface, where native ADGRL4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADGRL4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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