Seroatlas · Human Serome Atlas

FBLN7

Fibulin-7

Also known as: FBLN7_HUMAN, FLJ37440, TM14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53RD9
Gene: FBLN7
Ensembl: ENSG00000144152
Chromosome: 2
Canonical length: 439 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Plasma membrane,Cell Junctions
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Predicted to enable calcium ion binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in cell adhesion. Located in focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q53RD9|FBLN7
     1  MVPSSPRALF LLLLILACPE PRASQNCLSK QQLLSAIRQL QQLLKGQETR FAEGIRHMKS
    61  RLAALQNSVG RVGPDALPVS CPALNTPADG RKFGSKYLVD HEVHFTCNPG FRLVGPSSVV
   121  CLPNGTWTGE QPHCRGISEC SSQPCQNGGT CVEGVNQYRC ICPPGRTGNR CQHQAQTAAP
   181  EGSVAGDSAF SRAPRCAQVE RAQHCSCEAG FHLSGAAGDS VCQDVNECEL YGQEGRPRLC
   241  MHACVNTPGS YRCTCPGGYR TLADGKSCED VDECVGLQPV CPQGTTCINT GGSFQCVSPE
   301  CPEGSGNVSY VKTSPFQCER NPCPMDSRPC RHLPKTISFH YLSLPSNLKT PITLFRMATA
   361  SAPGRAGPNS LRFGIVGGNS RGHFVMQRSD RQTGDLILVQ NLEGPQTLEV DVDMSEYLDR
   421  SFQANHVSKV TIFVSPYDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBLN7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 12 nTPM
blood vessel: 12 nTPM
cerebral cortex: 10 nTPM
thyroid gland: 10 nTPM
cervix: 9.7 nTPM
lymph node: 9.2 nTPM

Single-cell type

oocytes: 166 nCPM
thyrotrophs: 81 nCPM
somatotrophs: 66 nCPM
myosatellite cells: 61 nCPM
ependymal cells: 55 nCPM
lactotrophs: 39 nCPM

Immune cell

T-reg: 37 nTPM
memory CD4 T-cell: 35 nTPM
naive CD4 T-cell: 30 nTPM
total PBMC: 6.2 nTPM
MAIT T-cell: 1.3 nTPM
naive CD8 T-cell: 1 nTPM

Brain region

pons: 24 nTPM
cerebral cortex: 18 nTPM
medulla oblongata: 15 nTPM
midbrain: 13 nTPM
thalamus: 13 nTPM
cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: 1.15
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell adhesion

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBLN7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBLN7 as an antibody target. Whether an autoantibody or antibody against FBLN7 could matter depends on whether native FBLN7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBLN7 is annotated as secreted, so native FBLN7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FBLN7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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