Seroatlas · Human Serome Atlas

NBPF26

NBPF family member NBPF26

Also known as: NBPFP_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B4DH59
Gene: NBPF26
Canonical length: 1673 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for NBPF26 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1673 residues, UniProt reviewed canonical sequence.

>B4DH59|NBPF26
     1  MPALRPALLW ALLALWLCWA APAHALQCRD GYEPCVNKGM CVTYHSGTGY CKCPEGFLGE
    61  YCQHRDPCEK NRCQNGGTCV AQAMLGKATC RCASGFTGED CQYSTPHPCF VSRPCLNGGT
   121  CHMLSRDTYE CTCQVGFTGK ECQWTDACLS HLCANGSTCT TVANQFSCKC LTGFTGQKCE
   181  TDVNECDIPG HCQHGGTCLN LPGSYQCQCL QGFTGQYCDR LYVPCAHSPC VNGGTCRQTG
   241  DFTFECNCLP VPDSTSSATN VSMVVSAGHW SSEKAEMNIL EINETLRPQL PENKQQLRNL
   301  KEKCFLTQLA GFLANRQKKY KYEECKDLIK FMLRNERQFK EEKLAEQLKQ AEELRQYKVL
   361  VHSQERELTQ LKEKLREGRD ASRSLNEHLQ ALLTPDEPDK SQGQDLQEQL AEGCRLAQHL
   421  VQKLSPENDE DEDEDVQVEE DEKVLESSAP REVQKTEESK VPEDSLEECA ITCSNSHGPC
   481  DSNQPHKNIK ITFEEDEVNS TLVVDRESSH DECQDALNIL PVPGPTSSAT NVSMVVSAGP
   541  LSGEKAAINI LEINEKLRPQ LAEKKQQFRN LKEKCFLTQL AGFLANQQNK YKYEECKDLI
   601  KSMLRNERQF KEEKLAEQLK QAEELRQYKV LVHAQERELT QLREKLREGR DASRSLNEHL
   661  QALLTPDEPD KSQGQDLQEQ LAEGCRLAQH LVQKLSPEND NDDDEDVQVE VAEKVQKSSA
   721  PREMQKAEEK EVPEDSLEEC AITCSNSHGP YDCNQPHRKT KITFEEDKVD STLIGSSSHV
   781  EWEDAVHIIP ENESDDEEEE EKGPVSPRNL QESEEEEVPQ ESWDEGYSTL SIPPEMLASY
   841  KSYSSTFHSL EEQQVCMAVD IGRHRWDQVK KEDHEATGPR LSRELLDEKG PEVLQDSLDR
   901  CYSTPSGCLE LTDSCQPYRS AFYVLEQQRV GLAVDMDEIE KYQEVEEDQD PSCPRLSGEL
   961  LDEKEPEVLQ ESLDRCYSTP SGCLELTDSC QPYRSAFYIL EQQRVGLAVD MDEIEKYQEV
  1021  EEDQDPSCPR LSGELLDEKE PEVLQESLDR CYSTPSGCLE LTDSCQPYRS AFYILEQQRV
  1081  GLAVDMDEIE KYQEVEEDQD PSCPRLSREL LDEKEPEVLQ DSLGRCYSTP SGYLELPDLG
  1141  QPYSSAVYSL EEQYLGLALD VDRIKKDQEE EEDQGPPCPR LSRELLEVVE PEVLQDSLDR
  1201  CYSTPSSCLE QPDSCQPYGS SFYALEEKHV GFSLDVGEIE KKGKGKKRRG RRSKKERRRG
  1261  RKEGEEDQNP PCPRLSRELL DEKGPEVLQD SLDRCYSTPS GCLELTDSCQ PYRSAFYILE
  1321  QQRVGLAVDM DEIEKYQEVE EDQDPSCPRL SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ
  1381  PDSCQPYGSS FYALEEKHVG FSLDVGEIEK YQEVEEDQDP SCPRLSRELL DEKEPEVLQD
  1441  SLGRCYSTPS GYLELPDLGQ PYSSAVYSLE EQYLGLALDV DRIKKDQEEE EDQGPPCPRL
  1501  SRELLEVVEP EVLQDSLDRC YSTPSSCLEQ PDSCQPYGSS FYALEEKHVG FSLDVGEIEK
  1561  KGKGKKRRGR RSKKERRRGR KEGEEDQNPP CPRLNSMLME VEEPEVLQDS LDICYSTPSM
  1621  YFELPDSFQH YRSVFYSFEE EHISFALYVD NRFFTLTVTS LHLVFQMGVI FPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBPF26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

skin: 31 nTPM
retina: 18 nTPM
epididymis: 16 nTPM
appendix: 15 nTPM
esophagus: 14 nTPM
smooth muscle: 13 nTPM

Single-cell type

neutrophils: 73 nCPM
sertoli cells: 73 nCPM
podocytes: 50 nCPM
bergmann glia: 42 nCPM
astrocytes: 38 nCPM
suprabasal keratinocytes: 33 nCPM

Immune cell

neutrophil: 7.3 nTPM
non-classical monocyte: 5.7 nTPM
eosinophil: 3.2 nTPM
basophil: 2.3 nTPM
classical monocyte: 2.3 nTPM
intermediate monocyte: 1.4 nTPM

Brain region

choroid plexus: 41 nTPM
cerebellum: 37 nTPM
thalamus: 31 nTPM
cerebral cortex: 30 nTPM
hypothalamus: 29 nTPM
medulla oblongata: 28 nTPM

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBPF26 as an antibody target. Whether an autoantibody or antibody against NBPF26 could matter depends on whether native NBPF26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBPF26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBPF26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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