Seroatlas · Human Serome Atlas

UMODL1

Uromodulin-like 1

Also known as: UROL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5DID0
Gene
UMODL1
Ensembl
ENSG00000177398
Chromosome
21
Canonical length
1318 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and peptidase inhibitor activity. Predicted to act upstream of or within several processes, including cellular response to gonadotropin-releasing hormone; regulation of granulosa cell apoptotic process; and regulation of ovarian follicle development. Predicted to be located in cytoplasm; external side of plasma membrane; and extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1318 residues, UniProt reviewed canonical sequence.

>Q5DID0|UMODL1
     1  MLRTSGLALL ALVSAVGPSQ ASGFTEKGLS LLGYQLCSHR VTHTVQKVEA VQTSYTSYVS
    61  CGGWIPWRRC PKMVYRTQYL VVEVPESRNV TDCCEGYEQL GLYCVLPLNQ SGQFTSRPGA
   121  CPAEGPEPST SPCSLDIDCP GLEKCCPWSG GRYCMAPAPQ APERDPVGSW YNVTILVKMD
   181  FKELQQVDPR LLNHMRLLHS LVTSALQPMA STVHHLHSAP GNASTTVSRL LLGLPRPLPV
   241  ADVSTLLGDI AKRVYEVISV QVQDVNECFY EELNACSGRE LCANLEGSYW CVCHQEAPAT
   301  SPRKLNLEWE DCPPVSDYVV LNVTSDSFQV SWRLNSTQNH TFHVRVYRGM ELLRSARTQS
   361  QALAVAGLEA GVLYRVKTSY QGCGADVSTT LTIKTNAQVF EVTIKIVNHN LTEKLLNRSS
   421  VEYQDFSRQL LHEVESSFPP VVSDLYRSGK LRMQIVSLQA GSVVVRLKLT VQDPGFPMGI
   481  STLAPILQPL LASTVFQIDR QGTRVQDWDE CVDSAEHDCS PAAWCINLEG SYTCQCRTTR
   541  DATPSRAGRA CEGDLVSPMG GGLSAATGVT VPGLGTGTAA LGLENFTLSP SPGYPQGTPA
   601  AGQAWTPEPS PRRGGSNVVG YDRNNTGKGV EQELQGNSIM EPPSWPSPTE DPTGHFLWHA
   661  TRSTRETLLN PTWLRNEDSG PSGSVDLPLT STLTALKTPA CVPVSIGRIM VSNVTSTGFH
   721  LAWEADLAMD STFQLTLTSM WSPAVVLETW NTSVTLSGLE PGVLHLVEIM AKACGKEGAR
   781  AHLKVRTAAR KLIGKVRIKN VRYSESFRNA SSQEYRDFLE LFFRMVRGSL PATMCQHMDA
   841  GGVRMEVVSV TNGSIVVEFH LLIIADVDVQ EVSAAFLTAF QTVPLLEVIR GDTFIQDYDE
   901  CERKEDDCVP GTSCRNTLGS FTCSCEGGAP DFPVEYSERP CEGDSPGNET WATSPERPLT
   961  TAGTKAAFVQ GTSPTPQGLP QRLNLTGAVR VLCEIEKVVV AIQKRFLQQE SIPESSLYLS
  1021  HPSCNVSHSN GTHVLLEAGW SECGTLMQSN MTNTVVRTTL RNDLSQEGII HHLKILSPIY
  1081  CAFQNDLLTS SGFTLEWGVY TIIEDLHGAG NFVTEMQLFI GDSPIPQNYS VSASDDVRIE
  1141  VGLYRQKSNL KVVLTECWAT PSSNARDPIT FSFINNSCPV PNTYTNVIEN GNSNKAQFKL
  1201  RIFSFINDSI VYLHCKLRVC MESPGATCKI NCNNFRLLQN SETSATHQMS WGPLIRSEGE
  1261  PPHAEAGLGA GYVVLIVVAI FVLVAGTATL LIVRYQRMNG RYNFKIQSNN FSYQVFYE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UMODL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
1 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 1 nTPM
  • testis: 0.8 nTPM
  • thymus: 0.3 nTPM
  • choroid plexus: 0.2 nTPM
  • small intestine: 0.2 nTPM
  • bone marrow: 0.1 nTPM

Single-cell type

  • thymocytes: 79 nCPM
  • fallopian tube ciliated cells: 13 nCPM
  • early spermatids: 11 nCPM
  • late spermatids: 9.6 nCPM
  • endometrial ciliated cells: 9.5 nCPM
  • renal collecting duct intercalated cells: 9.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 4.1 nTPM
  • thalamus: 1.3 nTPM
  • amygdala: 1.1 nTPM
  • midbrain: 0.9 nTPM
  • hippocampal formation: 0.7 nTPM
  • hypothalamus: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
-0.32
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UMODL1 as an antibody target. Whether an autoantibody or antibody against UMODL1 could matter depends on whether native UMODL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UMODL1 is annotated at the cell surface, where native UMODL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label UMODL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UMODL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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