Seroatlas · Human Serome Atlas

SVEP1

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Also known as: bA427L11.3, C9orf13, FLJ13529, POLYDOM, SVEP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4LDE5
Gene: SVEP1
Ensembl: ENSG00000165124
Chromosome: 9
Canonical length: 3571 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables integrin binding activity. Involved in negative regulation of vasoconstriction and positive regulation of platelet activation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

3571 residues, UniProt reviewed canonical sequence.

>Q4LDE5|SVEP1
     1  MWPRLAFCCW GLALVSGWAT FQQMSPSRNF SFRLFPETAP GAPGSIPAPP APGDEAAGSR
    61  VERLGQAFRR RVRLLRELSE RLELVFLVDD SSSVGEVNFR SELMFVRKLL SDFPVVPTAT
   121  RVAIVTFSSK NYVVPRVDYI STRRARQHKC ALLLQEIPAI SYRGGGTYTK GAFQQAAQIL
   181  LHARENSTKV VFLITDGYSN GGDPRPIAAS LRDSGVEIFT FGIWQGNIRE LNDMASTPKE
   241  EHCYLLHSFE EFEALARRAL HEDLPSGSFI QDDMVHCSYL CDEGKDCCDR MGSCKCGTHT
   301  GHFECICEKG YYGKGLQYEC TACPSGTYKP EGSPGGISSC IPCPDENHTS PPGSTSPEDC
   361  VCREGYRASG QTCELVHCPA LKPPENGYFI QNTCNNHFNA ACGVRCHPGF DLVGSSIILC
   421  LPNGLWSGSE SYCRVRTCPH LRQPKHGHIS CSTREMLYKT TCLVACDEGY RLEGSDKLTC
   481  QGNSQWDGPE PRCVERHCST FQMPKDVIIS PHNCGKQPAK FGTICYVSCR QGFILSGVKE
   541  MLRCTTSGKW NVGVQAAVCK DVEAPQINCP KDIEAKTLEQ QDSANVTWQI PTAKDNSGEK
   601  VSVHVHPAFT PPYLFPIGDV AIVYTATDLS GNQASCIFHI KVIDAEPPVI DWCRSPPPVQ
   661  VSEKVHAASW DEPQFSDNSG AELVITRSHT QGDLFPQGET IVQYTATDPS GNNRTCDIHI
   721  VIKGSPCEIP FTPVNGDFIC TPDNTGVNCT LTCLEGYDFT EGSTDKYYCA YEDGVWKPTY
   781  TTEWPDCAKK RFANHGFKSF EMFYKAARCD DTDLMKKFSE AFETTLGKMV PSFCSDAEDI
   841  DCRLEENLTK KYCLEYNYDY ENGFAIGPGG WGAANRLDYS YDDFLDTVQE TATSIGNAKS
   901  SRIKRSAPLS DYKIKLIFNI TASVPLPDER NDTLEWENQQ RLLQTLETIT NKLKRTLNKD
   961  PMYSFQLASE ILIADSNSLE TKKASPFCRP GSVLRGRMCV NCPLGTYYNL EHFTCESCRI
  1021  GSYQDEEGQL ECKLCPSGMY TEYIHSRNIS DCKAQCKQGT YSYSGLETCE SCPLGTYQPK
  1081  FGSRSCLSCP ENTSTVKRGA VNISACGVPC PEGKFSRSGL MPCHPCPRDY YQPNAGKAFC
  1141  LACPFYGTTP FAGSRSITEC SSFSSTFSAA EESVVPPASL GHIKKRHEIS SQVFHECFFN
  1201  PCHNSGTCQQ LGRGYVCLCP LGYTGLKCET DIDECSPLPC LNNGVCKDLV GEFICECPSG
  1261  YTGQRCEENI NECSSSPCLN KGICVDGVAG YRCTCVKGFV GLHCETEVNE CQSNPCLNNA
  1321  VCEDQVGGFL CKCPPGFLGT RCGKNVDECL SQPCKNGATC KDGANSFRCL CAAGFTGSHC
  1381  ELNINECQSN PCRNQATCVD ELNSYSCKCQ PGFSGKRCET EQSTGFNLDF EVSGIYGYVM
  1441  LDGMLPSLHA LTCTFWMKSS DDMNYGTPIS YAVDNGSDNT LLLTDYNGWV LYVNGREKIT
  1501  NCPSVNDGRW HHIAITWTSA NGIWKVYIDG KLSDGGAGLS VGLPIPGGGA LVLGQEQDKK
  1561  GEGFSPAESF VGSISQLNLW DYVLSPQQVK SLATSCPEEL SKGNVLAWPD FLSGIVGKVK
  1621  IDSKSIFCSD CPRLGGSVPH LRTASEDLKP GSKVNLFCDP GFQLVGNPVQ YCLNQGQWTQ
  1681  PLPHCERISC GVPPPLENGF HSADDFYAGS TVTYQCNNGY YLLGDSRMFC TDNGSWNGVS
  1741  PSCLDVDECA VGSDCSEHAS CLNVDGSYIC SCVPPYTGDG KNCAEPIKCK APGNPENGHS
  1801  SGEIYTVGAE VTFSCQEGYQ LMGVTKITCL ESGEWNHLIP YCKAVSCGKP AIPENGCIEE
  1861  LAFTFGSKVT YRCNKGYTLA GDKESSCLAN SSWSHSPPVC EPVKCSSPEN INNGKYILSG
  1921  LTYLSTASYS CDTGYSLQGP SIIECTASGI WDRAPPACHL VFCGEPPAIK DAVITGNNFT
  1981  FRNTVTYTCK EGYTLAGLDT IECLADGKWS RSDQQCLAVS CDEPPIVDHA SPETAHRLFG
  2041  DIAFYYCSDG YSLADNSQLL CNAQGKWVPP EGQDMPRCIA HFCEKPPSVS YSILESVSKA
  2101  KFAAGSVVSF KCMEGFVLNT SAKIECMRGG QWNPSPMSIQ CIPVRCGEPP SIMNGYASGS
  2161  NYSFGAMVAY SCNKGFYIKG EKKSTCEATG QWSSPIPTCH PVSCGEPPKV ENGFLEHTTG
  2221  RIFESEVRYQ CNPGYKSVGS PVFVCQANRH WHSESPLMCV PLDCGKPPPI QNGFMKGENF
  2281  EVGSKVQFFC NEGYELVGDS SWTCQKSGKW NKKSNPKCMP AKCPEPPLLE NQLVLKELTT
  2341  EVGVVTFSCK EGHVLQGPSV LKCLPSQQWN DSFPVCKIVL CTPPPLISFG VPIPSSALHF
  2401  GSTVKYSCVG GFFLRGNSTT LCQPDGTWSS PLPECVPVEC PQPEEIPNGI IDVQGLAYLS
  2461  TALYTCKPGF ELVGNTTTLC GENGHWLGGK PTCKAIECLK PKEILNGKFS YTDLHYGQTV
  2521  TYSCNRGFRL EGPSALTCLE TGDWDVDAPS CNAIHCDSPQ PIENGFVEGA DYSYGAIIIY
  2581  SCFPGFQVAG HAMQTCEESG WSSSIPTCMP IDCGLPPHID FGDCTKLKDD QGYFEQEDDM
  2641  MEVPYVTPHP PYHLGAVAKT WENTKESPAT HSSNFLYGTM VSYTCNPGYE LLGNPVLICQ
  2701  EDGTWNGSAP SCISIECDLP TAPENGFLRF TETSMGSAVQ YSCKPGHILA GSDLRLCLEN
  2761  RKWSGASPRC EAISCKKPNP VMNGSIKGSN YTYLSTLYYE CDPGYVLNGT ERRTCQDDKN
  2821  WDEDEPICIP VDCSSPPVSA NGQVRGDEYT FQKEIEYTCN EGFLLEGARS RVCLANGSWS
  2881  GATPDCVPVR CATPPQLANG VTEGLDYGFM KEVTFHCHEG YILHGAPKLT CQSDGNWDAE
  2941  IPLCKPVNCG PPEDLAHGFP NGFSFIHGGH IQYQCFPGYK LHGNSSRRCL SNGSWSGSSP
  3001  SCLPCRCSTP VIEYGTVNGT DFDCGKAARI QCFKGFKLLG LSEITCEADG QWSSGFPHCE
  3061  HTSCGSLPMI PNAFISETSS WKENVITYSC RSGYVIQGSS DLICTEKGVW SQPYPVCEPL
  3121  SCGSPPSVAN AVATGEAHTY ESEVKLRCLE GYTMDTDTDT FTCQKDGRWF PERISCSPKK
  3181  CPLPENITHI LVHGDDFSVN RQVSVSCAEG YTFEGVNISV CQLDGTWEPP FSDESCSPVS
  3241  CGKPESPEHG FVVGSKYTFE STIIYQCEPG YELEGNRERV CQENRQWSGG VAICKETRCE
  3301  TPLEFLNGKA DIENRTTGPN VVYSCNRGYS LEGPSEAHCT ENGTWSHPVP LCKPNPCPVP
  3361  FVIPENALLS EKEFYVDQNV SIKCREGFLL QGHGIITCNP DETWTQTSAK CEKISCGPPA
  3421  HVENAIARGV HYQYGDMITY SCYSGYMLEG FLRSVCLENG TWTSPPICRA VCRFPCQNGG
  3481  ICQRPNACSC PEGWMGRLCE EPICILPCLN GGRCVAPYQC DCPPGWTGSR CHTAVCQSPC
  3541  LNGGKCVRPN RCHCLSSWTG HNCSRKRRTG F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SVEP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

placenta: 58 nTPM
adipose tissue: 37 nTPM
breast: 23 nTPM
lung: 19 nTPM
blood vessel: 12 nTPM
vagina: 12 nTPM

Single-cell type

fibro-adipogenic progenitors: 857 nCPM
adipocytes: 723 nCPM
syncytiotrophoblasts: 610 nCPM
mesothelial cells: 470 nCPM
fibroblasts: 350 nCPM
epicardial cells: 214 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 24 nTPM
basal ganglia: 24 nTPM
white matter: 18 nTPM
midbrain: 16 nTPM
thalamus: 14 nTPM
cerebral cortex: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 1.88
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SVEP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SVEP1 as an antibody target. Whether an autoantibody or antibody against SVEP1 could matter depends on whether native SVEP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SVEP1 is annotated as secreted, so native SVEP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SVEP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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