Seroatlas · Human Serome Atlas

SUSD1

Sushi domain-containing protein 1

Also known as: DKFZP761E1824, SUSD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWL2
Gene: SUSD1
Ensembl: ENSG00000106868
Chromosome: 9
Canonical length: 747 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>Q6UWL2|SUSD1
     1  MGRGPWDAGP SRRLLPLLLL LGLARGAAGA PGPDGLDVCA TCHEHATCQQ REGKKICICN
    61  YGFVGNGRTQ CVDKNECQFG ATLVCGNHTS CHNTPGGFYC ICLEGYRATN NNKTFIPNDG
   121  TFCTDIDECE VSGLCRHGGR CVNTHGSFEC YCMDGYLPRN GPEPFHPTTD ATSCTEIDCG
   181  TPPEVPDGYI IGNYTSSLGS QVRYACREGF FSVPEDTVSS CTGLGTWESP KLHCQEINCG
   241  NPPEMRHAIL VGNHSSRLGG VARYVCQEGF ESPGGKITSV CTEKGTWRES TLTCTEILTK
   301  INDVSLFNDT CVRWQINSRR INPKISYVIS IKGQRLDPME SVREETVNLT TDSRTPEVCL
   361  ALYPGTNYTV NISTAPPRRS MPAVIGFQTA EVDLLEDDGS FNISIFNETC LKLNRRSRKV
   421  GSEHMYQFTV LGQRWYLANF SHATSFNFTT REQVPVVCLD LYPTTDYTVN VTLLRSPKRH
   481  SVQITIATPP AVKQTISNIS GFNETCLRWR SIKTADMEEM YLFHIWGQRW YQKEFAQEMT
   541  FNISSSSRDP EVCLDLRPGT NYNVSLRALS SELPVVISLT TQITEPPLPE VEFFTVHRGP
   601  LPRLRLRKAK EKNGPISSYQ VLVLPLALQS TFSCDSEGAS SFFSNASDAD GYVAAELLAK
   661  DVPDDAMEIP IGDRLYYGEY YNAPLKRGSD YCIILRITSE WNKVRRHSCA VWAQVKDSSL
   721  MLLQMAGVGL GSLAVVIILT FLSFSAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

placenta: 14 nTPM
bone marrow: 13 nTPM
kidney: 11 nTPM
urinary bladder: 11 nTPM
stomach: 9.9 nTPM
lung: 9.1 nTPM

Single-cell type

renal collecting duct intercalated cells: 254 nCPM
renal collecting duct principal cells: 246 nCPM
pdcs: 234 nCPM
renal connecting tubule cells: 225 nCPM
platelets: 220 nCPM
sertoli cells: 171 nCPM

Immune cell

plasmacytoid DC: 44 nTPM
eosinophil: 11 nTPM
basophil: 6.1 nTPM
non-classical monocyte: 5.3 nTPM
NK-cell: 3.1 nTPM
intermediate monocyte: 2.9 nTPM

Brain region

hypothalamus: 31 nTPM
pons: 29 nTPM
midbrain: 28 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 18 nTPM
medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 1.03
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUSD1 as an antibody target. Whether an autoantibody or antibody against SUSD1 could matter depends on whether native SUSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUSD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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