Seroatlas · Human Serome Atlas

NOTCH2NLA

Notch homolog 2 N-terminal-like protein A

Also known as: N2N, NOTCH2NL, NT2NA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3S9
Gene: NOTCH2NLA
Ensembl: ENSG00000264343
Chromosome: 1
Canonical length: 236 aa
Protein class: Disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Enables Notch binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Predicted to be located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q7Z3S9|NOTCH2NLA
     1  MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT CRCASGFTGE
    61  DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG KECQWTDACL SHPCANGSTC
   121  TTVANQFSCK CLTGFTGQKC ETDVNECDIP GHCQHGGTCL NLPGSYQCQC LQGFTGQYCD
   181  SLYVPCAPSP CVNGGTCRQT GDFTFECNCL PETVRRGTEL WERDREVWNG KEHDEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOTCH2NLA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

testis: 32 nTPM
liver: 27 nTPM
choroid plexus: 27 nTPM
bone marrow: 23 nTPM
cervix: 22 nTPM
skin: 21 nTPM

Single-cell type

tuft cells: 23 nCPM
medullary thymic epithelial cells: 2.4 nCPM
pdcs: 1.3 nCPM
conjunctival goblet cells: 1 nCPM
podocytes: 0.5 nCPM
fibro-adipogenic progenitors: 0.4 nCPM

Immune cell

eosinophil: 90 nTPM
memory B-cell: 76 nTPM
myeloid DC: 61 nTPM
plasmacytoid DC: 49 nTPM
classical monocyte: 47 nTPM
naive B-cell: 44 nTPM

Brain region

choroid plexus: 86 nTPM
cerebral cortex: 67 nTPM
thalamus: 57 nTPM
medulla oblongata: 54 nTPM
hippocampal formation: 53 nTPM
white matter: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.61

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOTCH2NLA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOTCH2NLA as an antibody target. Whether an autoantibody or antibody against NOTCH2NLA could matter depends on whether native NOTCH2NLA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOTCH2NLA is annotated as secreted, so native NOTCH2NLA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NOTCH2NLA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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