Seroatlas · Human Serome Atlas

HMCN2

Hemicentin-2

Also known as: DKFZp434P0216, FLJ23816, HMCN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDA2
Gene: HMCN2
Ensembl: ENSG00000148357
Chromosome: 9
Canonical length: 5079 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

5079 residues, UniProt reviewed canonical sequence.

>Q8NDA2|HMCN2
     1  MMPGAPLLRL LTAVSAAVAV AVAGAPGTVM PPTTGDATLA FVFDVTGSMW DELMQVIDGA
    61  SRILERSLSR RSQAIANYAL VPFHDPDIGP VTLTADPTVF QRELRELYVQ GGGDCPEMSV
   121  GAIKAAVEVA NPGSFIYVFS DARAKDYHKK EELLRLLQLK QSQVVFVLTG DCGDRTHPGY
   181  LAYEEIAATS SGQVFHLDKQ QVTEVLKWVE SAIQASKVHL LSTDHEEEGE HTWRLPFDPS
   241  LKEVTISLSG PGPEIEVQDP LGRILQEDEG LNVLLNIPDS AKVVAFKPEH PGLWSIKVYS
   301  SGRHSVRITG VSNIDFRAGF STQPLLDLNH TLEWPLQGVP ISLVINSTGL KAPGRLDSVE
   361  LAQSSGKPLL TLPTKPLSNG STHQLWGGPP FHTPKERFYL KVKGKDHEGN PLLRVSGVSY
   421  SGVAPGAPLV SMAPRIHGYL HQPLLVSCSV HSALPFRLQL RRGEARLGEE RHFQESGNSS
   481  WEILRASKAE EGTYECTAVS RAGTGRAKAQ IVVTDPPPQL VPAPNVTVSP GETAVLSCRV
   541  LGEAPYNLTW VRDWRVLPAS TGRVAQLADL SLEISGIIPT DGGRYQCVAS NANGVTRASV
   601  WLLVREAPQV SIHTSSQHFS QGVEVKVSCS ASGYPTPHIS WSRESQALQE DSRIHVDAQG
   661  TLIIQGVAPE DAGNYSCQAT NEVGTDQETV TLYYTDPPSV SAVNAVVLVA VGEEAVLVCE
   721  ASGVPPPRVI WYRGGLEMIL APEGSSSGKL RIPAAQERDA GTYTCRAVNE LGDASAEIQL
   781  AVGHAPQLTE LPRDVTVELG RSALLACRAT GRPPPTVTWR RGDGQPLGLR LGAGRGSRSR
   841  QPDSGVLFFE SVAPEDQAPY VCEARNVFGK VQAEARLIVT GHAPPQIASS APTVRVLEGQ
   901  PVSLPCIVLA GRPLPERHWL KDGRPLPPGS RHSIRADGSL HLDRALQEHA GRYSCVATNT
   961  AGSQHRDVEL VVQVPPRIHP TATHHITNEG VAASLPCVAS GVPAPTITWT KETNALTSRG
  1021  PHYNVSKEGT LLIAQPSAQD AGAYVCTATN TVGFSSQEMR LSVNTKPRIH MNGSRNADVP
  1081  LQVTAKAGEE VTLDCEAKGS PPPLVTWTKD SRPVPPITNR YGLLPSGSLR LAQVQVGDSG
  1141  HYECTASNPA GSASHRYVLG VQVPPQVQPG PRVLKVLVGE ALDLNCVAEG NPEPQLSWSK
  1201  DGVVLQGRGP QGSVHFAAIR TSDAGRYRCE ASNSAGVDAW EVELRVLEPP HWGADETSGL
  1261  LERVAGENAS LPCPARGTPK PQVTWRKGPS SEPLHGQPGV AVLEEGSLFL ASVSPADSGD
  1321  YECQATNEVG STSRRAKLVV YVPPSIREDG RKANVSGMAG QSLTLECDAN GFPVPEIVWL
  1381  KDAQLIPKVG GHRLLDEGQS LHFPRIQEGD SGLYSCRAEN QAGTAQRDFH LLVLTPPSVL
  1441  GAGAAQEVLG LAGADVELQC WTSGVPTPQV EWTKDRQPVL PGGPHLQVQE DGQVLRITGS
  1501  HVGDEGRYQC VAFSPAGQQA RDFQLRVHAP PTIWGSNETG EVAVMEDHLV QLLCEARGVP
  1561  TPNITWFKDG ALLPTSTKVV YTRGGRQLQL GRAQSSDAGV YTCKASNAVG AAEKATRLDV
  1621  YVPPTIEGAG GRPYVVKAVA GRPVALECVA RGHPSPTLSW HHEGLPVAES NESRLETDGS
  1681  VLRLESPGEA SSGLYSCVAS SPAGEAVLQY SVEVQVPPQL LVAEGLGQVT TIVGQPLELP
  1741  CQASGSPVPT IQWLQNGRPA EELAGVQVAS QGTTLHIDHV ELDHSGLFAC QATNEAGTAG
  1801  AEVEVSVHEF PSVSIIGGEN ITAPFLQPVT LQCIGDGVPT PSLRWWKDGV ALAAFGGNLQ
  1861  IEKVDLRDEG IYTCAATNLA GESKREVALK VLVPPNIEPG PVNKAVLENA SVTLECLASG
  1921  VPPPDVSWFK GHQPVSSWMG VTVSVDGRVL RIEQAQLSDA GSYRCVASNV AGSTELRYGL
  1981  RVNVPPRITL PPSLPGPVLV NTPVRLTCNA TGAPSPTLMW LKDGNPVSPA GTPGLQVFPG
  2041  GRVLTLASAR ASDSGRYSCV AVSAVGEDRQ DVVLQVHMPP SILGEELNVS VVANESVALE
  2101  CQSHAMPPPV LSWWKDGRPL EPRPGVHLSA DKALLQVDRA DVWDAGHYTC EALNQAGHSE
  2161  KHYNLNVWVA PVFPLRESHT LTVREGHPTR LSCECRGVPF PKISWRKDGQ PLPGEGAGLQ
  2221  HVSAVGRLLY LGQAQLAQEG TYTCECSNVV GNSSQDLQLE VHVPPQIAGP REPPTQVSVV
  2281  QDGVATLECN ATGKPPPTVT WERDGQPVGA ELGLQLQNQG QSLHVERAQA AHTGRYSCVA
  2341  ENLAGRAERK FELSVLVPPE LIGDLDPLTN ITAALHSPLT LLCEAMGIPP PAIRWFRGEE
  2401  PVSPGEDTYL LAGGWMLKMT QTQEQDSGLY SCLASNEAGE ARRNFSVEVL VPPSIENEDL
  2461  EEVIKVLDGQ TAHLMCNVTG HPQPKLTWFK DGRPLARGDA HHISPDGVLL QVLQANLSSA
  2521  GHYSCIAANA VGEKTKHFQL SVLLAPTILG GAEDSADEEV TVTVNNPISL ICEALAFPSP
  2581  NITWMKDGAP FEASRNIQLL PGTHGLQILN AQKEDAGQYT CVVTNELGEA VKNYHVEVLI
  2641  PPSISKDDPL AEVGVKEVKT KVNSTLTLEC ESWAVPPPTI RWYKDGQPVT PSSRLQVLGE
  2701  GRLLQIQPTQ VSDSGRYLCV ATNVAGEDDQ DFNVLIQVPP MFQKVGDFSA AFEILSREEE
  2761  ARGGVTEYRE IVENNPAYLY CDTNAIPPPD LTWYREDQPL SAGDEVSVLQ GGRVLQIPLV
  2821  RAENAGRYSC KASNEVGEDW LHYELLVLTP PVILGDTEEL VEEVTVNASS TVSLQCPALG
  2881  NPVPTISWLQ NGLPFSPSPR LQVLEDGQVL QVSTAEVADA ASYMCVAENQ AGSAEKLFTL
  2941  RVQVPPRIAG LDLEQVTAIL NSSVSLPCDV HAHPNPEVTW YKDSQALSLG EEVFLLPGTH
  3001  TLQLGRARLS DSGMYTCEAL NAAGRDQKLV QLSVLVPPAF RQAPRGPQDA VLVRVGDKAV
  3061  LSCETDALPE PTVTWYKDGQ PLVLAQRTQA LRGGQRLEIQ EAQVSDKGLY SCKVSNVAGE
  3121  AVRTFTLTVQ VPPTFENPKT ETVSQVAGSP LVLTCDVSGV PAPTVTWLKD RMPVESSAVH
  3181  GVVSRGGRLQ LSRLQPAQAG TYTCVAENTQ AEARKDFVVA VLVAPRIRSS GVAREHHVLE
  3241  GQEVRLDCEA DGQPPPDVAW LKDGSPLGQD MGPHLRFYLD GGSLVLKGLR ASDAGAYTCV
  3301  AHNPAGEDAR LHTVNVLVPP TIKQGADGSG TLVSRPGELV TMVCPVRGSP PIHVSWLKDG
  3361  LPLPLSQRTL LHGSGHTLRI SKVQLADAGI FTCVAASPAG VADRNFTLQV QVPPVLEPVE
  3421  FQNDVVVVRG SLVELPCEAR GVPLPLVSWM KDGEPLLSQS LEQGPSLQLE AVGAGDSGTY
  3481  SCVAVSEAGE ARRHFQLTVM EPPHIEDSGQ PTELSLTPGA PMELLCDAQG TPQPNITWHK
  3541  DGQALTRLEN NSRATRVLRV ENVQVRDAGL YTCLAESPAG AIEKSFRVRV QAPPNIVGPR
  3601  GPRFVVGLAP GQLVLECSVE AEPAPKITWH RDGIVLQEDA HTQFPERGRF LQLQALSTAD
  3661  SGDYSCTARN AAGSTSVAFR VEIHTVPTIR SGPPAVNVSV NQTALLPCQA DGVPAPLVSW
  3721  RKDRVPLDPR SPRFEILPEG SLRIQPVLAQ DAGHYLCLAS NSAGSDRQGR DLRVLEPPAI
  3781  APSPSNLTLT AHTPALLPCE ASGSPKPLVV WWKDGQKLDF RLQQGAYRLL PSNALLLTAP
  3841  GPQDSAQFEC VVSNEVGEAH RLYQVTVHVP PTIADDQTDF TVTMMAPVVL TCHSTGIPAP
  3901  TVSWSKAGAQ LGARGSGYRV SPSGALEIGQ ALPIHAGRYT CSARNSAGVA HKHVFLTVQA
  3961  SPVVKPLPSV VRAVAEEEVL LPCEASGIPR PTITWQKEGL NVATGVSTQV LPGGQLRIAH
  4021  ASPEDAGNYL CIAKNSAGSA MGKTRLVVQV PPVIENGLPD LSTTEGSHAF LPCKARGSPE
  4081  PNITWDKDGQ PVSGAEGKFT IQPSGELLVK NLEGQDAGTY TCTAENAVGR ARRRVHLTIL
  4141  VLPVFTTLPG DRSLRLGDRL WLRCAARGSP TPRIGWTVND RPVTEGVSEQ DGGSTLQRAA
  4201  VSREDSGTYV CWAENRVGRT QAVSFVHVKE APVLQGEAFS YLVEPVGGSI QLDCVVRGDP
  4261  VPDIHWIKDG LPLRGSHLRH QLQNGSLTIR RTERDDAGRY QCLAENEMGV AKKVVILVLQ
  4321  SAPVFQVEPQ DMTVRSGDDV ALRCQATGEP TPTIEWLQAG QPLRASRRLR TLPDGSLWLE
  4381  NVETGDAGTY DCVAHNLLGS ATARAFLVVR GEPQGSWGSM TGVINGRKFG VATLNTSVMQ
  4441  EAHSGVSSIH SSIRHVPANV GPLMRVLVVT IAPIYWALAR ESGEALNGHS LTGGRFRQES
  4501  HVEFATGELL TMTQVARGLD PDGLLLLDVV VNGVVPESLA DADLQVQDFE EHYVQTGPGQ
  4561  LFVGSTQRFF QGGLPSFLRC NHSIQYNAAR GPQPQLVQHL RASAISSAFD PEAEALRFQL
  4621  ATALQAEENE VGCPEGFELD SQGAFCVDRD ECSGGPSPCS HACLNAPGRF SCTCPTGFAL
  4681  AWDDRNCRDV DECAWDAHLC REGQRCVNLL GSYRCLPDCG PGFRVADGAG CEDVDECLEG
  4741  LDDCHYNQLC ENTPGGHRCS CPRGYRMQGP SLPCLDVNEC LQLPKACAYQ CHNLQGSYRC
  4801  LCPPGQTLLR DGKACTSLER NGQNVTTVSH RGPLLPWLRP WASIPGTSYH AWVSLRPGPM
  4861  ALSSVGRAWC PPGFIRQNGV CTDLDECRVR NLCQHACRNT EGSYQCLCPA GYRLLPSGKN
  4921  CQDINECEEE SIECGPGQMC FNTRGSYQCV DTPCPATYRQ GPSPGTCFRR CSQDCGTGGP
  4981  STLQYRLLPL PLGVRAHHDV ARLTAFSEVG VPANRTELSM LEPDPRSPFA LRPLRAGLGA
  5041  VYTRRALTRA GLYRLTVRAA APRHQSVFVL LIAVSPYPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMCN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

colon: 37 nTPM
skeletal muscle: 23 nTPM
endometrium: 21 nTPM
small intestine: 15 nTPM
blood vessel: 14 nTPM
heart muscle: 9.7 nTPM

Single-cell type

myosatellite cells: 811 nCPM
fibro-adipogenic progenitors: 521 nCPM
early spermatids: 53 nCPM
enterocytes: 41 nCPM
smooth muscle cells: 38 nCPM
late spermatids: 31 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 9.2 nTPM
medulla oblongata: 4.5 nTPM
spinal cord: 3 nTPM
hypothalamus: 2.5 nTPM
cerebral cortex: 1.8 nTPM
midbrain: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 1.07

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMCN2 as an antibody target. Whether an autoantibody or antibody against HMCN2 could matter depends on whether native HMCN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMCN2 is annotated as secreted, so native HMCN2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HMCN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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