Seroatlas · Human Serome Atlas

MEGF6

Multiple epidermal growth factor-like domains protein 6

Also known as: EGFL3, MEGF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75095
Gene: MEGF6
Ensembl: ENSG00000162591
Chromosome: 1
Canonical length: 1541 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Microtubules,Cytokinetic bridge
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1541 residues, UniProt reviewed canonical sequence.

>O75095|MEGF6
     1  MSFLEEARAA GRAVVLALVL LLLPAVPVGA SVPPRPLLPL QPGMPHVCAE QELTLVGRRQ
    61  PCVQALSHTV PVWKAGCGWQ AWCVGHERRT VYYMGYRQVY TTEARTVLRC CRGWMQQPDE
   121  EGCLSAECSA SLCFHGGRCV PGSAQPCHCP PGFQGPRCQY DVDECRTHNG GCQHRCVNTP
   181  GSYLCECKPG FRLHTDSRTC LAINSCALGN GGCQHHCVQL TITRHRCQCR PGFQLQEDGR
   241  HCVRRSPCAN RNGSCMHRCQ VVRGLARCEC HVGYQLAADG KACEDVDECA AGLAQCAHGC
   301  LNTQGSFKCV CHAGYELGAD GRQCYRIEME IVNSCEANNG GCSHGCSHTS AGPLCTCPRG
   361  YELDTDQRTC IDVDDCADSP CCQQVCTNNP GGYECGCYAG YRLSADGCGC EDVDECASSR
   421  GGCEHHCTNL AGSFQCSCEA GYRLHEDRRG CSPLEEPMVD LDGELPFVRP LPHIAVLQDE
   481  LPQLFQDDDV GADEEEAELR GEHTLTEKFV CLDDSFGHDC SLTCDDCRNG GTCLLGLDGC
   541  DCPEGWTGLI CNETCPPDTF GKNCSFSCSC QNGGTCDSVT GACRCPPGVS GTNCEDGCPK
   601  GYYGKHCRKK CNCANRGRCH RLYGACLCDP GLYGRFCHLT CPPWAFGPGC SEECQCVQPH
   661  TQSCDKRDGS CSCKAGFRGE RCQAECELGY FGPGCWQACT CPVGVACDSV SGECGKRCPA
   721  GFQGEDCGQE CPVGTFGVNC SSSCSCGGAP CHGVTGQCRC PPGRTGEDCE ADCPEGRWGL
   781  GCQEICPACQ HAARCDPETG ACLCLPGFVG SRCQDVCPAG WYGPSCQTRC SCANDGHCHP
   841  ATGHCSCAPG WTGFSCQRAC DTGHWGPDCS HPCNCSAGHG SCDAISGLCL CEAGYVGPRC
   901  EQQCPQGHFG PGCEQRCQCQ HGAACDHVSG ACTCPAGWRG TFCEHACPAG FFGLDCRSAC
   961  NCTAGAACDA VNGSCLCPAG RRGPRCAETC PAHTYGHNCS QACACFNGAS CDPVHGQCHC
  1021  APGWMGPSCL QACPAGLYGD NCRHSCLCQN GGTCDPVSGH CACPEGWAGL ACEKECLPRD
  1081  VRAGCRHSGG CLNGGLCDPH TGRCLCPAGW TGDKCQSPCL RGWFGEACAQ RCSCPPGAAC
  1141  HHVTGACRCP PGFTGSGCEQ ACPPGSFGED CAQMCQCPGE NPACHPATGT CSCAAGYHGP
  1201  SCQQRCPPGR YGPGCEQLCG CLNGGSCDAA TGACRCPTGF LGTDCNLTCP QGRFGPNCTH
  1261  VCGCGQGAAC DPVTGTCLCP PGRAGVRCER GCPQNRFGVG CEHTCSCRNG GLCHASNGSC
  1321  SCGLGWTGRH CELACPPGRY GAACHLECSC HNNSTCEPAT GTCRCGPGFY GQACEHPCPP
  1381  GFHGAGCQGL CWCQHGAPCD PISGRCLCPA GFHGHFCERG CEPGSFGEGC HQRCDCDGGA
  1441  PCDPVTGLCL CPPGRSGATC NLDCRRGQFG PSCTLHCDCG GGADCDPVSG QCHCVDGYMG
  1501  PTCREGGPLR LPENPSLAQG SAGTLPASSR PTSRSGGPAR H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEGF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 86 nTPM
skin: 42 nTPM
prostate: 27 nTPM
adipose tissue: 24 nTPM
cervix: 23 nTPM
vagina: 22 nTPM

Single-cell type

epicardial cells: 100 nCPM
hepatic stellate cells: 71 nCPM
basal prostatic cells: 50 nCPM
lymphatic endothelial cells: 43 nCPM
alveolar cells type 2: 40 nCPM
müller glia: 39 nCPM

Immune cell

eosinophil: 1.9 nTPM
basophil: 1 nTPM
neutrophil: 0.8 nTPM
T-reg: 0.8 nTPM
naive CD4 T-cell: 0.3 nTPM
naive B-cell: 0.2 nTPM

Brain region

midbrain: 11 nTPM
thalamus: 6.3 nTPM
pons: 6.2 nTPM
medulla oblongata: 6.1 nTPM
hypothalamus: 5.3 nTPM
amygdala: 4.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MEGF6.

Disease | ImmuneIEDB

Conditions an epitope on MEGF6 was assayed in.

viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEGF6 as an antibody target. Whether an autoantibody or antibody against MEGF6 could matter depends on whether native MEGF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEGF6 is annotated as secreted, so native MEGF6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MEGF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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