Seroatlas · Human Serome Atlas

FBLN1

Fibulin-1

Also known as: FBLN, FBLN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23142
Gene
FBLN1
Ensembl
ENSG00000077942
Chromosome
22
Canonical length
703 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Endoplasmic reticulum
Secretome location
Secreted to extracellular matrix
Quaternary structure
Homomultimer

OverviewNCBI Gene

Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

703 residues, UniProt reviewed canonical sequence.

>P23142|FBLN1
     1  MERAAPSRRV PLPLLLLGGL ALLAAGVDAD VLLEACCADG HRMATHQKDC SLPYATESKE
    61  CRMVQEQCCH SQLEELHCAT GISLANEQDR CATPHGDNAS LEATFVKRCC HCCLLGRAAQ
   121  AQGQSCEYSL MVGYQCGQVF QACCVKSQET GDLDVGGLQE TDKIIEVEEE QEDPYLNDRC
   181  RGGGPCKQQC RDTGDEVVCS CFVGYQLLSD GVSCEDVNEC ITGSHSCRLG ESCINTVGSF
   241  RCQRDSSCGT GYELTEDNSC KDIDECESGI HNCLPDFICQ NTLGSFRCRP KLQCKSGFIQ
   301  DALGNCIDIN ECLSISAPCP IGHTCINTEG SYTCQKNVPN CGRGYHLNEE GTRCVDVDEC
   361  APPAEPCGKG HRCVNSPGSF RCECKTGYYF DGISRMCVDV NECQRYPGRL CGHKCENTLG
   421  SYLCSCSVGF RLSVDGRSCE DINECSSSPC SQECANVYGS YQCYCRRGYQ LSDVDGVTCE
   481  DIDECALPTG GHICSYRCIN IPGSFQCSCP SSGYRLAPNG RNCQDIDECV TGIHNCSINE
   541  TCFNIQGGFR CLAFECPENY RRSAATLQQE KTDTVRCIKS CRPNDVTCVF DPVHTISHTV
   601  ISLPTFREFT RPEEIIFLRA ITPPHPASQA NIIFDITEGN LRDSFDIIKR YMDGMTVGVV
   661  RQVRPIVGPF HAVLKLEMNY VVGGVVSHRN VVNVHIFVSE YWF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBLN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
1,775 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 1,775 nTPM
  • cervix: 1,099 nTPM
  • vagina: 909 nTPM
  • heart muscle: 749 nTPM
  • urinary bladder: 744 nTPM
  • gallbladder: 634 nTPM

Single-cell type

  • fibroblasts: 1,820 nCPM
  • syncytiotrophoblasts: 1,557 nCPM
  • decidual stromal cells: 1,117 nCPM
  • extravillous trophoblasts: 994 nCPM
  • cytotrophoblasts: 846 nCPM
  • migrating cytotrophoblasts: 731 nCPM

Immune cell

  • non-classical monocyte: 2.5 nTPM
  • plasmacytoid DC: 1.2 nTPM
  • myeloid DC: 0.5 nTPM
  • basophil: 0.4 nTPM
  • intermediate monocyte: 0.3 nTPM
  • neutrophil: 0.2 nTPM

Brain region

  • choroid plexus: 1,731 nTPM
  • hippocampal formation: 129 nTPM
  • basal ganglia: 92 nTPM
  • cerebral cortex: 87 nTPM
  • cerebellum: 87 nTPM
  • midbrain: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.92
gnomAD missense Z
1.43
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBLN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBLN1 as an antibody target. Whether an autoantibody or antibody against FBLN1 could matter depends on whether native FBLN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBLN1 is annotated as secreted, so native FBLN1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FBLN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBLN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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