VWCE

Protein identityUniProt · HPA

UniProt accession

Q96DN2

Gene

VWCE

Ensembl

ENSG00000167992

Chromosome

11

Canonical length

955 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Vesicles,Cytosol

Secretome location

Secreted - unknown location

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in cellular response to virus. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

955 residues, UniProt reviewed canonical sequence.

>Q96DN2|VWCE
     1  MWAGLLLRAA CVALLLPGAP ARGYTGRKPP GHFAAERRRL GPHVCLSGFG SGCCPGWAPS
    61  MGGGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPET HGPCGEYGCD LTCNHGGCQE
   121  VARVCPVGFS MTETAVGIRC TDIDECVTSS CEGHCVNTEG GFVCECGPGM QLSADRHSCQ
   181  DTDECLGTPC QQRCKNSIGS YKCSCRTGFH LHGNRHSCVD VNECRRPLER RVCHHSCHNT
   241  VGSFLCTCRP GFRLRADRVS CEAFPKAVLA PSAILQPRQH PSKMLLLLPE AGRPALSPGH
   301  SPPSGAPGPP AGVRTTRLPS PTPRLPTSSP SAPVWLLSTL LATPVPTASL LGNLRPPSLL
   361  QGEVMGTPSS PRGPESPRLA AGPSPCWHLG AMHESRSRWT EPGCSQCWCE DGKVTCEKVR
   421  CEAACSHPIP SRDGGCCPSC TGCFHSGVVR AEGDVFSPPN ENCTVCVCLA GNVSCISPEC
   481  PSGPCQTPPQ TDCCTCVPVR CYFHGRWYAD GAVFSGGGDE CTTCVCQNGE VECSFMPCPE
   541  LACPREEWRL GPGQCCFTCQ EPTPSTGCSL DDNGVEFPIG QIWSPGDPCE LCICQADGSV
   601  SCKRTDCVDS CPHPIRIPGQ CCPDCSAGCT YTGRIFYNNE TFPSVLDPCL SCICLLGSVA
   661  CSPVDCPITC TYPFHPDGEC CPVCRDCNYE GRKVANGQVF TLDDEPCTRC TCQLGEVSCE
   721  KVPCQRACAD PALLPGDCCS SCPDSLSPLE EKQGLSPHGN VAFSKAGRSL HGDTEAPVNC
   781  SSCPGPPTAS PSRPVLHLLQ LLLRTNLMKT QTLPTSPAGA HGPHSLALGL TATFPGEPGA
   841  SPRLSPGPST PPGAPTLPLA SPGAPQPPPV TPERSFSASG AQIVSRWPPL PGTLLTEASA
   901  LSMMDPSPSK TPITLLGPRV LSPTTSRLST ALAATTHPGP QQPPVGASRG EESTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VWCE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

16 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VWCE.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.8

gnomAD pLI

0

gnomAD missense Z

0.9

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to virus

Molecular functions

• calcium ion binding

Cellular components

• cytoplasm
• extracellular region

Protein domainsUniProt · Pfam · InterPro

• EGF-type aspartate/asparagine hydroxylation site
• EGF-like domain
• VWFC domain
• EGF-like calcium-binding domain
• Growth factor receptor cysteine-rich domain superfamily
• EGF-like calcium-binding, conserved site
• Complement Clr-like EGF domain
• von Willebrand factor C/EGF & Fibrillin
• von Willebrand factor type C domain
• Complement Clr-like EGF-like
• VWC2L-like domain

KeywordsUniProt

• Calcium
• Disulfide bond
• EGF-like domain
• Glycoprotein
• Repeat
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of VWCE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NUFIP2