Seroatlas · Human Serome Atlas

DLK2

Protein delta homolog 2

Also known as: DLK2_HUMAN, EGFL9, MGC2487

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UY11
Gene: DLK2
Ensembl: ENSG00000171462
Chromosome: 6
Canonical length: 383 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli,Vesicles

OverviewNCBI Gene

Predicted to enable Notch binding activity. Involved in negative regulation of Notch signaling pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>Q6UY11|DLK2
     1  MPSGCRCLHL VCLLCILGAP GQPVRADDCS SHCDLAHGCC APDGSCRCDP GWEGLHCERC
    61  VRMPGCQHGT CHQPWQCICH SGWAGKFCDK DEHICTTQSP CQNGGQCMYD GGGEYHCVCL
   121  PGFHGRDCER KAGPCEQAGS PCRNGGQCQD DQGFALNFTC RCLVGFVGAR CEVNVDDCLM
   181  RPCANGATCL DGINRFSCLC PEGFAGRFCT INLDDCASRP CQRGARCRDR VHDFDCLCPS
   241  GYGGKTCELV LPVPDPPTTV DTPLGPTSAV VVPATGPAPH SAGAGLLRIS VKEVVRRQEA
   301  GLGEPSLVAL VVFGALTAAL VLATVLLTLR AWRRGVCPPG PCCYPAPHYA PACQDQECQV
   361  SMLPAGLPLP RDLPPEPGKT TAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

prostate: 12 nTPM
skin: 12 nTPM
esophagus: 12 nTPM
cerebellum: 10 nTPM
basal ganglia: 8.4 nTPM
salivary gland: 7.6 nTPM

Single-cell type

breast myoepithelial cells: 80 nCPM
epididymal basal cells: 70 nCPM
basal prostatic cells: 51 nCPM
respiratory basal cells: 42 nCPM
esophageal basal cells: 35 nCPM
salivary basal cells: 34 nCPM

Immune cell

MAIT T-cell: 0.8 nTPM
NK-cell: 0.7 nTPM
memory CD4 T-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
basophil: 0.3 nTPM

Brain region

cerebellum: 14 nTPM
cerebral cortex: 9.8 nTPM
basal ganglia: 8.7 nTPM
hypothalamus: 8.1 nTPM
hippocampal formation: 7.2 nTPM
amygdala: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.78
gnomAD missense Z: 1.93
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLK2 as an antibody target. Whether an autoantibody or antibody against DLK2 could matter depends on whether native DLK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DLK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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