Seroatlas · Human Serome Atlas

NOTCH2NLR

Notch homolog 2 N-terminal-like protein R

Also known as: NT2NR_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A096LNW5
Gene
NOTCH2NLR
Canonical length
274 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for NOTCH2NLR in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>A0A096LNW5|NOTCH2NLR
     1  MPALRPALLW ALLALWLCWA APAHALQCRD GYEPCVNKGM CVTYHSGTGY CKCPEGFLGE
    61  YCQHRDPCEK NRCQNGGTCV AQAMLGKATC RCASGFTGED CQYSTPHPCF VSRPCLNGGT
   121  CHMLSRDTYE CTCQVGFTGK ECQWTDACLS HLCANGSTCT TVANQFSCKC LTGFTGQKCE
   181  TDVNECDIPG HCQHGGTCLN LPGSYQCQCL QGFTGQYCDR LYVPCAHSPC VNGGTCRQTG
   241  DFTFECNCLP ETVRNKRNRA LGKRQASLEW KRTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOTCH2NLR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
4.2 nTPM

Expression across tissuesHPA

Tissue

  • skin: 4.2 nTPM
  • epididymis: 3.2 nTPM
  • blood vessel: 2.6 nTPM
  • testis: 2.6 nTPM
  • adipose tissue: 1.9 nTPM
  • esophagus: 1.9 nTPM

Single-cell type

  • esophageal apical cells: 4.5 nCPM
  • late primary spermatocytes: 4.1 nCPM
  • decidual stromal cells: 2.6 nCPM
  • gastric progenitor cells: 2.6 nCPM
  • extravillous trophoblasts: 2.5 nCPM
  • late spermatids: 2.5 nCPM

Immune cell

  • basophil: 8 nTPM
  • neutrophil: 5.8 nTPM
  • non-classical monocyte: 5.2 nTPM
  • eosinophil: 3.3 nTPM
  • intermediate monocyte: 2.8 nTPM
  • classical monocyte: 2.4 nTPM

Brain region

  • choroid plexus: 5.3 nTPM
  • medulla oblongata: 4.9 nTPM
  • hypothalamus: 4.4 nTPM
  • midbrain: 4.3 nTPM
  • thalamus: 4.2 nTPM
  • cerebral cortex: 4.1 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOTCH2NLR as an antibody target. Whether an autoantibody or antibody against NOTCH2NLR could matter depends on whether native NOTCH2NLR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOTCH2NLR is annotated as secreted, so native NOTCH2NLR circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NOTCH2NLR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NOTCH2NLR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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