Seroatlas · Human Serome Atlas

RBX1

E3 ubiquitin-protein ligase RBX1

Also known as: BA554C12.1, RBX1_HUMAN, RNF75, ROC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62877
Gene: RBX1
Ensembl: ENSG00000100387
Chromosome: 22
Canonical length: 108 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>P62877|RBX1
     1  MAAAMDVDTP SGTNSGAGKK RFEVKKWNAV ALWAWDIVVD NCAICRNHIM DLCIECQANQ
    61  ASATSEECTV AWGVCNHAFH FHCISRWLKT RQVCPLDNRE WEFQKYGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

tongue: 94 nTPM
spinal cord: 90 nTPM
skeletal muscle: 82 nTPM
midbrain: 74 nTPM
amygdala: 73 nTPM
heart muscle: 71 nTPM

Single-cell type

platelets: 1,075 nCPM
esophageal apical cells: 1,001 nCPM
megakaryocytes: 890 nCPM
extravillous trophoblasts: 811 nCPM
syncytiotrophoblasts: 789 nCPM
esophageal suprabasal cells: 710 nCPM

Immune cell

total PBMC: 250 nTPM
plasmacytoid DC: 211 nTPM
non-classical monocyte: 155 nTPM
basophil: 153 nTPM
T-reg: 138 nTPM
intermediate monocyte: 134 nTPM

Brain region

white matter: 53 nTPM
spinal cord: 45 nTPM
medulla oblongata: 44 nTPM
cerebellum: 43 nTPM
pons: 41 nTPM
hypothalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.95
gnomAD missense Z: 2.38
DepMap mean gene effect: -1.44
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBX1 as an antibody target. Whether an autoantibody or antibody against RBX1 could matter depends on whether native RBX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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