Seroatlas · Human Serome Atlas

SOCS3

Suppressor of cytokine signaling 3

Also known as: CIS3, Cish3, SOCS-3, SOCS3_HUMAN, SSI-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14543
Gene
SOCS3
Ensembl
ENSG00000184557
Chromosome
17
Canonical length
225 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>O14543|SOCS3
     1  MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL
    61  SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV
   121  LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR
   181  PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOCS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
480 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 480 nTPM
  • lung: 225 nTPM
  • fallopian tube: 188 nTPM
  • gallbladder: 179 nTPM
  • urinary bladder: 175 nTPM
  • bone marrow: 119 nTPM

Single-cell type

  • decidual stromal cells: 909 nCPM
  • vascular endothelial cells: 755 nCPM
  • smooth muscle cells: 598 nCPM
  • epididymal basal cells: 516 nCPM
  • pericytes: 504 nCPM
  • medullary thymic epithelial cells: 482 nCPM

Immune cell

  • neutrophil: 9.6 nTPM
  • naive CD4 T-cell: 3.1 nTPM
  • memory CD4 T-cell: 2.2 nTPM
  • MAIT T-cell: 1.9 nTPM
  • T-reg: 1.3 nTPM
  • myeloid DC: 1.1 nTPM

Brain region

  • medulla oblongata: 59 nTPM
  • thalamus: 40 nTPM
  • pons: 24 nTPM
  • spinal cord: 23 nTPM
  • midbrain: 22 nTPM
  • cerebral cortex: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.75
gnomAD missense Z
1.86
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SOCS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOCS3 as an antibody target. Whether an autoantibody or antibody against SOCS3 could matter depends on whether native SOCS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOCS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOCS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SOCS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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