Seroatlas · Human Serome Atlas

ASB9

Ankyrin repeat and SOCS box protein 9

Also known as: ASB9_HUMAN, DKFZP564L0862, FLJ20636, MGC4954

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DX5
Gene: ASB9
Ensembl: ENSG00000102048
Chromosome: X
Canonical length: 294 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>Q96DX5|ASB9
     1  MDGKQGGMDG SKPAGPRDFP GIRLLSNPLM GDAVSDWSPM HEAAIHGHQL SLRNLISQGW
    61  AVNIITADHV SPLHEACLGG HLSCVKILLK HGAQVNGVTA DWHTPLFNAC VSGSWDCVNL
   121  LLQHGASVQP ESDLASPIHE AARRGHVECV NSLIAYGGNI DHKISHLGTP LYLACENQQR
   181  ACVKKLLESG ADVNQGKGQD SPLHAVARTA SEELACLLMD FGADTQAKNA EGKRPVELVP
   241  PESPLAQLFL EREGPPSLMQ LCRLRIRKCF GIQQHHKITK LVLPEDLKQF LLHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
liver: 16 nTPM
kidney: 16 nTPM
spleen: 11 nTPM
pancreas: 9.1 nTPM
stomach: 3.8 nTPM

Single-cell type

undifferentiated spermatogonia: 161 nCPM
differentiating spermatogonia: 140 nCPM
sertoli cells: 41 nCPM
parietal cells: 30 nCPM
renal collecting duct intercalated cells: 29 nCPM
melanocytes: 23 nCPM

Immune cell

myeloid DC: 1.6 nTPM
naive CD4 T-cell: 1.2 nTPM
MAIT T-cell: 0.7 nTPM
classical monocyte: 0.6 nTPM
basophil: 0.4 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

medulla oblongata: 2.6 nTPM
cerebellum: 2.3 nTPM
pons: 2.1 nTPM
amygdala: 2 nTPM
cerebral cortex: 1.9 nTPM
choroid plexus: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.7
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB9 as an antibody target. Whether an autoantibody or antibody against ASB9 could matter depends on whether native ASB9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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