COMMD1
COMM domain-containing protein 1
Also known as: C2orf5, COMD1_HUMAN, MGC27155, MURR1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N668
- Gene
- COMMD1
- Ensembl
- ENSG00000173163
- Chromosome
- 2
- Canonical length
- 190 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables several functions, including phosphatidylinositol-3,4-bisphosphate binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including Golgi to plasma membrane transport; negative regulation of protein localization to cell surface; and regulation of protein metabolic process. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity. Located in cytosol; endosome; and nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
190 residues, UniProt reviewed canonical sequence.
>Q8N668|COMMD1
1 MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK
61 SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR
121 GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE
181 SISTLISQPNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against COMMD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 85 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 85 nTPM
- skeletal muscle: 63 nTPM
- choroid plexus: 58 nTPM
- tongue: 54 nTPM
- liver: 53 nTPM
- kidney: 51 nTPM
Single-cell type
- myonuclei: 490 nCPM
- syncytiotrophoblasts: 371 nCPM
- sertoli cells: 357 nCPM
- choroid plexus epithelial cells: 297 nCPM
- late primary spermatocytes: 290 nCPM
- esophageal suprabasal cells: 278 nCPM
Immune cell
- myeloid DC: 145 nTPM
- plasmacytoid DC: 139 nTPM
- classical monocyte: 136 nTPM
- total PBMC: 128 nTPM
- intermediate monocyte: 120 nTPM
- NK-cell: 114 nTPM
Brain region
- white matter: 35 nTPM
- cerebral cortex: 34 nTPM
- cerebellum: 32 nTPM
- spinal cord: 31 nTPM
- basal ganglia: 30 nTPM
- choroid plexus: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.89
- gnomAD pLI
- 0.22
- gnomAD missense Z
- 0.04
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cholesterol homeostasis
- copper ion homeostasis
- Golgi to plasma membrane transport
- low-density lipoprotein particle clearance
- negative regulation of hypoxia-inducible factor-1alpha signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of protein localization to cell surface
- negative regulation of sodium ion transmembrane transport
- nucleotide-excision repair
- plasma membrane to endosome transport
- positive regulation of endosome to plasma membrane protein transport
- positive regulation of protein localization to cell surface
- positive regulation of protein ubiquitination
- protein destabilization
- protein localization to cell surface
- protein transport
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of cholesterol import
Molecular functions
- copper ion binding
- identical protein binding
- phosphatidic acid binding
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-3,4-bisphosphate binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein homodimerization activity
- sodium channel inhibitor activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- COMM domain
- COMM domain
- COMMD1 N-terminal domain
- COMM domain-containing protein 1
- COMMD1 N-terminal domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of COMMD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads COMMD1 as an antibody target. Whether an autoantibody or antibody against COMMD1 could matter depends on whether native COMMD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
COMMD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label COMMD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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