Seroatlas · Human Serome Atlas

SOCS2

Suppressor of cytokine signaling 2

Also known as: CIS2, Cish2, SOCS-2, SOCS2_HUMAN, SSI-2, SSI2, STATI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14508
Gene
SOCS2
Ensembl
ENSG00000120833
Chromosome
12
Canonical length
198 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>O14508|SOCS2
     1  MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PQAARLAKAL RELGQTGWYW GSMTVNEAKE
    61  KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD
   121  SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL YLTKPLYTSA PSLQHLCRLT INKCTGAIWG
   181  LPLPTRLKDY LEEYKFQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOCS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • cervix: 88 nTPM
  • endometrium: 85 nTPM
  • smooth muscle: 84 nTPM
  • prostate: 74 nTPM
  • adipose tissue: 66 nTPM
  • breast: 62 nTPM

Single-cell type

  • decidual stromal cells: 188 nCPM
  • hematopoietic stem cells: 165 nCPM
  • prostatic glandular cells: 136 nCPM
  • pituitary stem cells: 130 nCPM
  • vascular endothelial cells: 128 nCPM
  • lymphatic endothelial cells: 100 nCPM

Immune cell

  • basophil: 179 nTPM
  • MAIT T-cell: 34 nTPM
  • memory CD4 T-cell: 31 nTPM
  • naive CD4 T-cell: 31 nTPM
  • NK-cell: 27 nTPM
  • gdT-cell: 26 nTPM

Brain region

  • choroid plexus: 45 nTPM
  • cerebral cortex: 22 nTPM
  • midbrain: 20 nTPM
  • thalamus: 19 nTPM
  • hippocampal formation: 17 nTPM
  • hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.63
gnomAD missense Z
1.37
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SOCS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOCS2 as an antibody target. Whether an autoantibody or antibody against SOCS2 could matter depends on whether native SOCS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOCS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOCS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SOCS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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