Seroatlas · Human Serome Atlas

SOCS4

Suppressor of cytokine signaling 4

Also known as: SOCS4_HUMAN, SOCS7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXH5
Gene: SOCS4
Ensembl: ENSG00000180008
Chromosome: 14
Canonical length: 440 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>Q8WXH5|SOCS4
     1  MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE TVNGIEKTEV
    61  SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR
   121  KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPINSKSDE WVSTDLSQTE LRDGQLKRRN
   181  MEENINCFSH TNVQPCVITT DNALCREGPM TGSVMNLVSN NSIEDSDMDS DDEILTLCTS
   241  SRKRNKPKWD LDDEILQLET PPKYHTQIDY VHCLVPDLLQ INNNPCYWGV MDKYAAEALL
   301  EGKPEGTFLL RDSAQEDYLF SVSFRRYSRS LHARIEQWNH NFSFDAHDPC VFHSPDITGL
   361  LEHYKDPSAC MFFEPLLSTP LIRTFPFSLQ HICRTVICNC TTYDGIDALP IPSSMKLYLK
   421  EYHYKSKVRV LRIDAPEQQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOCS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

retina: 10 nTPM
lymph node: 8.3 nTPM
thymus: 7.5 nTPM
appendix: 7.4 nTPM
spleen: 7.1 nTPM
tonsil: 7.1 nTPM

Single-cell type

megakaryocytes: 56 nCPM
neutrophil progenitors: 50 nCPM
endometrial ciliated cells: 49 nCPM
fallopian tube ciliated cells: 46 nCPM
thymocytes: 44 nCPM
megakaryocyte progenitors: 43 nCPM

Immune cell

NK-cell: 1.8 nTPM
non-classical monocyte: 1.8 nTPM
intermediate monocyte: 1.3 nTPM
MAIT T-cell: 1.3 nTPM
classical monocyte: 1.2 nTPM
eosinophil: 1.2 nTPM

Brain region

hypothalamus: 20 nTPM
white matter: 20 nTPM
medulla oblongata: 19 nTPM
spinal cord: 19 nTPM
midbrain: 17 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SOCS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOCS4 as an antibody target. Whether an autoantibody or antibody against SOCS4 could matter depends on whether native SOCS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOCS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOCS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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