Seroatlas · Human Serome Atlas

DCUN1D5

DCN1-like protein 5

Also known as: DCNL5_HUMAN, FLJ32431, MGC2714

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTE7
Gene: DCUN1D5
Ensembl: ENSG00000137692
Chromosome: 11
Canonical length: 237 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables cullin family protein binding activity. Involved in DNA damage response; positive regulation of protein neddylation; and regulation of cell growth. Located in nucleus and spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q9BTE7|DCUN1D5
     1  MPVKKKRKSP GVAAAVAEDG GLKKCKISSY CRSQPPARLI SGEEHFSSKK CLAWFYEYAG
    61  PDEVVGPEGM EKFCEDIGVE PENIIMLVLA WKLEAESMGF FTKEEWLKGM TSLQCDCTEK
   121  LQNKFDFLRS QLNDISSFKN IYRYAFDFAR DKDQRSLDID TAKSMLALLL GRTWPLFSVF
   181  YQYLEQSKYR VMNKDQWYNV LEFSRTVHAD LSNYDEDGAW PVLLDEFVEW QKVRQTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCUN1D5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 13 nTPM
skeletal muscle: 12 nTPM
esophagus: 11 nTPM
testis: 9.6 nTPM
liver: 9.1 nTPM
pancreas: 8.9 nTPM

Single-cell type

oocytes: 193 nCPM
early primary spermatocytes: 150 nCPM
esophageal suprabasal cells: 144 nCPM
differentiating spermatogonia: 141 nCPM
esophageal basal cells: 133 nCPM
gastric progenitor cells: 122 nCPM

Immune cell

NK-cell: 15 nTPM
basophil: 13 nTPM
T-reg: 12 nTPM
memory B-cell: 11 nTPM
plasmacytoid DC: 11 nTPM
memory CD4 T-cell: 11 nTPM

Brain region

cerebellum: 24 nTPM
spinal cord: 18 nTPM
hypothalamus: 18 nTPM
midbrain: 18 nTPM
hippocampal formation: 18 nTPM
cerebral cortex: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 0.99
gnomAD missense Z: 2.28
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCUN1D5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCUN1D5 as an antibody target. Whether an autoantibody or antibody against DCUN1D5 could matter depends on whether native DCUN1D5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCUN1D5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCUN1D5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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