COPS7A
COP9 signalosome complex subunit 7a
Also known as: CSN7A, CSN7A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UBW8
- Gene
- COPS7A
- Ensembl
- ENSG00000111652
- Chromosome
- 12
- Canonical length
- 275 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]
Canonical amino-acid sequenceUniProt
275 residues, UniProt reviewed canonical sequence.
>Q9UBW8|COPS7A
1 MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP NVRELAESDF
61 ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS VVTLAAKVKC IPYAVLLEAL
121 ALRNVRQLED LVIEAVYADV LRGSLDQRNQ RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG
181 CEVVLSGIEE QVSRANQHKE QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT
241 ELREPAPGTN QRQPSKKASK GKGLRGSAKI WSKSNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against COPS7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 97 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 97 nTPM
- cerebral cortex: 94 nTPM
- tongue: 92 nTPM
- choroid plexus: 76 nTPM
- heart muscle: 74 nTPM
- parathyroid gland: 68 nTPM
Single-cell type
- esophageal apical cells: 97 nCPM
- cytotrophoblasts: 86 nCPM
- esophageal suprabasal cells: 85 nCPM
- hofbauer cells: 83 nCPM
- decidual stromal cells: 76 nCPM
- migrating cytotrophoblasts: 73 nCPM
Immune cell
- eosinophil: 86 nTPM
- basophil: 86 nTPM
- intermediate monocyte: 73 nTPM
- myeloid DC: 65 nTPM
- non-classical monocyte: 59 nTPM
- classical monocyte: 57 nTPM
Brain region
- thalamus: 86 nTPM
- midbrain: 77 nTPM
- medulla oblongata: 76 nTPM
- pons: 75 nTPM
- cerebral cortex: 74 nTPM
- hypothalamus: 74 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.69
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 1.72
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of COPS7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads COPS7A as an antibody target. Whether an autoantibody or antibody against COPS7A could matter depends on whether native COPS7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
COPS7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label COPS7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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