ASB7

Protein identityUniProt · HPA

UniProt accession

Q9H672

Gene

ASB7

Ensembl

ENSG00000183475

Chromosome

15

Canonical length

318 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q9H672|ASB7
     1  MLHHHCRRNP ELQEELQIQA AVAAGDVHTV RKMLEQGYSP NGRDANGWTL LHFSAARGKE
    61  RCVRVFLEHG ADPTVKDLIG GFTALHYAAM HGRARIARLM LESEYRSDII NAKSNDGWTP
   121  LHVAAHYGRD SFVRLLLEFK AEVDPLSDKG TTPLQLAIIR ERSSCVKILL DHNANIDIQN
   181  GFLLRYAVIK SNHSYCRMFL QRGADTNLGR LEDGQTPLHL SALRDDVLCA RMLYNYGADT
   241  NTRNYEGQTP LAVSISISGS SRPCLDFLQE VTRQPRNLQD LCRIKIRQCI GLQNLKLLDE
   301  LPIAKVMKDY LKHKFDDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.28

gnomAD pLI

0.98

gnomAD missense Z

3.27

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intracellular signal transduction
• proteasome-mediated ubiquitin-dependent protein catabolic process
• protein ubiquitination
• regulation of heterochromatin organization

Molecular functions

• ubiquitin-like ligase-substrate adaptor activity

Cellular components

• Cul5-RING ubiquitin ligase complex
• cytosol
• heterochromatin

Protein domainsUniProt · Pfam · InterPro

• SOCS box domain
• Ankyrin repeat
• SOCS box-like domain superfamily
• Ankyrin repeat-containing domain superfamily
• SOCS box
• Ankyrin repeats (3 copies)
• Ankyrin repeat and SOCS box protein 7, SOCS box domain

KeywordsUniProt

• ANK repeat
• Chromosome
• Nucleus
• Phosphoprotein
• Repeat
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of ASB7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CBX5
• CUL5
• HIF1AN
• HMBOX1
• RNF7