Seroatlas · Human Serome Atlas

COPS6

COP9 signalosome complex subunit 6

Also known as: CSN6, CSN6_HUMAN, MOV34-34KD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L5N1
Gene
COPS6
Ensembl
ENSG00000168090
Chromosome
7
Canonical length
327 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q7L5N1|COPS6
     1  MAAAAAAAAA TNGTGGSSGM EVDAAVVPSV MACGVTGSVS VALHPLVILN ISDHWIRMRS
    61  QEGRPVQVIG ALIGKQEGRN IEVMNSFELL SHTVEEKIII DKEYYYTKEE QFKQVFKELE
   121  FLGWYTTGGP PDPSDIHVHK QVCEIIESPL FLKLNPMTKH TDLPVSVFES VIDIINGEAT
   181  MLFAELTYTL ATEEAERIGV DHVARMTATG SGENSTVAEH LIAQHSAIKM LHSRVKLILE
   241  YVKASEAGEV PFNHEILREA YALCHCLPVL STDKFKTDFY DQCNDVGLMA YLGTITKTCN
   301  TMNQFVNKFN VLYDRQGIGR RMRGLFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
143 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 143 nTPM
  • tongue: 143 nTPM
  • choroid plexus: 117 nTPM
  • basal ganglia: 110 nTPM
  • heart muscle: 107 nTPM
  • cerebral cortex: 104 nTPM

Single-cell type

  • esophageal apical cells: 380 nCPM
  • esophageal suprabasal cells: 345 nCPM
  • decidual stromal cells: 310 nCPM
  • gastric progenitor cells: 291 nCPM
  • late spermatids: 289 nCPM
  • esophageal basal cells: 253 nCPM

Immune cell

  • basophil: 232 nTPM
  • T-reg: 227 nTPM
  • myeloid DC: 212 nTPM
  • intermediate monocyte: 207 nTPM
  • non-classical monocyte: 196 nTPM
  • classical monocyte: 188 nTPM

Brain region

  • white matter: 77 nTPM
  • basal ganglia: 72 nTPM
  • cerebellum: 72 nTPM
  • spinal cord: 71 nTPM
  • cerebral cortex: 70 nTPM
  • hypothalamus: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
2.31
DepMap mean gene effect
-1.54
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPS6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPS6 as an antibody target. Whether an autoantibody or antibody against COPS6 could matter depends on whether native COPS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPS6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COPS6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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