Seroatlas · Human Serome Atlas

LRRC28

Leucine-rich repeat-containing protein 28

Also known as: FLJ34269, FLJ45242, LRC28_HUMAN, MGC24976

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86X40
Gene: LRRC28
Ensembl: ENSG00000168904
Chromosome: 15
Canonical length: 367 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Mitochondria

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q86X40|LRRC28
     1  MASELCKTIS VARLEKHKNL FLNYRNLHHF PLELLKDEGL QYLERLYMKR NSLTSLPENL
    61  AQKLPNLVEL YLHSNNIVVV PEAIGSLVKL QCLDLSDNAL EIVCPEIGRL RALRHLRLAN
   121  NQLQFLPPEV GDLKELQTLD ISTNRLLTLP ERLHMCLSLQ YLTVDRNRLW YVPRHLCQLP
   181  SLNELSMAGN RLAFLPLDLG RSRELQYVYV DNNIHLKGLP SYLYNKVIGC SGCGAPIQVS
   241  EVKLLSFSSG QRTVFLPAEV KAIGTEHDHV LPLQELAMRG LYHTYHSLLK DLNFLSPISL
   301  PRSLLELLHC PLGHCHRCSE PMFTIVYPKL FPLRETPMAG LHQWKTTVSF VAYCCSTQCL
   361  QTFDLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

liver: 44 nTPM
testis: 27 nTPM
thymus: 21 nTPM
pancreas: 18 nTPM
kidney: 18 nTPM
skeletal muscle: 18 nTPM

Single-cell type

late spermatids: 636 nCPM
thymocytes: 184 nCPM
late primary spermatocytes: 184 nCPM
distal convoluted tubule cells: 168 nCPM
early spermatids: 154 nCPM
enterocytes: 151 nCPM

Immune cell

eosinophil: 32 nTPM
basophil: 23 nTPM
T-reg: 10 nTPM
classical monocyte: 9.3 nTPM
myeloid DC: 8.4 nTPM
non-classical monocyte: 8 nTPM

Brain region

cerebral cortex: 12 nTPM
basal ganglia: 9.4 nTPM
cerebellum: 9.3 nTPM
choroid plexus: 9.1 nTPM
white matter: 8.9 nTPM
hippocampal formation: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC28 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CUL5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC28 as an antibody target. Whether an autoantibody or antibody against LRRC28 could matter depends on whether native LRRC28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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