Seroatlas · Human Serome Atlas

COMMD2

COMM domain-containing protein 2

Also known as: COMD2_HUMAN, HSPC042

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86X83
Gene: COMMD2
Ensembl: ENSG00000114744
Chromosome: 3
Canonical length: 199 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q86X83|COMMD2
     1  MLLELSEEHK EHLAFLPQVD SAVVAEFGRI AVEFLRRGAN PKIYEGAARK LNVSSDTVQH
    61  GVEGLTYLLT ESSKLMISEL DFQDSVFVLG FSEELNKLLL QLYLDNRKEI RTILSELAPS
   121  LPSYHNLEWR LDVQLASRSL RQQIKPAVTI KLHLNQNGDH NTKVLQTDPA TLLHLVQQLE
   181  QALEEMKTNH CRRVVRNIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMMD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

breast: 14 nTPM
ovary: 13 nTPM
thyroid gland: 13 nTPM
placenta: 13 nTPM
endometrium: 13 nTPM
lung: 12 nTPM

Single-cell type

oocytes: 83 nCPM
extravillous trophoblasts: 78 nCPM
early primary spermatocytes: 75 nCPM
alveolar cells type 1: 72 nCPM
cytotrophoblasts: 66 nCPM
gastric progenitor cells: 65 nCPM

Immune cell

basophil: 17 nTPM
non-classical monocyte: 12 nTPM
eosinophil: 11 nTPM
NK-cell: 9.7 nTPM
intermediate monocyte: 9.5 nTPM
MAIT T-cell: 8.5 nTPM

Brain region

white matter: 13 nTPM
cerebral cortex: 11 nTPM
cerebellum: 11 nTPM
basal ganglia: 11 nTPM
spinal cord: 11 nTPM
medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

COMM domain
COMM domain
COMMD2-7/10, HN domain
COMM domain-containing protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMMD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMMD2 as an antibody target. Whether an autoantibody or antibody against COMMD2 could matter depends on whether native COMMD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMMD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMMD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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